Two different mutations in the cytoplasmic domain of the integrin beta 4 subunit in nonlethal forms of epidermolysis bullosa prevent interaction of beta 4 with plectin

The integrin alpha 6 beta 4 plays a crucial role in the assembly and maintenance of hemidesmosomes. Previous work has shown that the recruitment of plectin into hemidesmosomes is dependent on beta 4 and involves a region of the beta 4 cytoplasmic domain, which contains the first two fibronectin (FNI...

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Veröffentlicht in:	Journal of investigative dermatology 2001-12, Vol.117 (6), p.1405
Hauptverfasser:	Koster, J, Kuikman, I, Kreft, M, Sonnenberg, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD - chemistry Antigens, CD - genetics Antigens, CD - metabolism COS Cells Cytoplasm Cytoskeleton - metabolism DNA, Complementary Epidermolysis Bullosa - genetics Epidermolysis Bullosa - metabolism Hemidesmosomes - metabolism Integrin beta4 Intermediate Filament Proteins - metabolism Mutagenesis - physiology Mutation, Missense Plectin Protein Structure, Tertiary Two-Hybrid System Techniques Yeasts
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