Rhabdomyosarcoma arising in mediastinal teratoma in an adult man: a case report
We report a case of rhabdomyosarcoma which occurred in a mediastinal teratoma in a 44-year-old man. Presentation symptoms were chest pain, hoarseness and a cough. Diagnosis was fortuitous, performed by the histological and immunohistochemical study of a mediastinal tumour biopsy specimen that showed...
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| Veröffentlicht in: | Annals of oncology 2002-02, Vol.13 (2), p.323-326 |
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| container_end_page | 326 |
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| container_issue | 2 |
| container_start_page | 323 |
| container_title | Annals of oncology |
| container_volume | 13 |
| creator | OMEZZINE, N KHOUATRA, C LARIVE, S FREYER, G ISAAC-PINET, S GERINIERE, L DROZ, J.-P SOUQUET, P.-J |
| description | We report a case of rhabdomyosarcoma which occurred in a mediastinal teratoma in a 44-year-old man. Presentation symptoms were chest pain, hoarseness and a cough. Diagnosis was fortuitous, performed by the histological and immunohistochemical study of a mediastinal tumour biopsy specimen that showed embryonal carcinoma and yolk sac tumour components associated with the rhabdomyosarcoma. After cisplatin-based chemotherapy (bleomycin-etoposide-cisplatin), surgical resection of the residual mediastinal tumour was performed. Histological and immunohistochemical study of this tumour confirmed the presence of mature teratoma and embryonal rhabdomyosarcoma. Evolution was marked by a local extension of the mediastinal tumour, occurrence of multiple metastases and bone marrow involvement. The patient died 8 months after diagnosis despite chemotherapy and radiotherapy. A review of the literature reveals that the development of rhabdomyosarcoma in primary mediastinal teratomas is unusual in adults. The diagnostic, therapeutic and prognostic implications of such an association are reviewed. |
| doi_str_mv | 10.1093/annonc/mdf022 |
| format | Article |
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Presentation symptoms were chest pain, hoarseness and a cough. Diagnosis was fortuitous, performed by the histological and immunohistochemical study of a mediastinal tumour biopsy specimen that showed embryonal carcinoma and yolk sac tumour components associated with the rhabdomyosarcoma. After cisplatin-based chemotherapy (bleomycin-etoposide-cisplatin), surgical resection of the residual mediastinal tumour was performed. Histological and immunohistochemical study of this tumour confirmed the presence of mature teratoma and embryonal rhabdomyosarcoma. Evolution was marked by a local extension of the mediastinal tumour, occurrence of multiple metastases and bone marrow involvement. The patient died 8 months after diagnosis despite chemotherapy and radiotherapy. A review of the literature reveals that the development of rhabdomyosarcoma in primary mediastinal teratomas is unusual in adults. The diagnostic, therapeutic and prognostic implications of such an association are reviewed.</description><identifier>ISSN: 0923-7534</identifier><identifier>EISSN: 1569-8041</identifier><identifier>DOI: 10.1093/annonc/mdf022</identifier><identifier>PMID: 11886012</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; Biological and medical sciences ; Dermatology ; Humans ; Male ; Mediastinal Neoplasms - complications ; Medical sciences ; Pneumology ; Rhabdomyosarcoma, Embryonal - etiology ; Teratoma - complications ; Tumors of the respiratory system and mediastinum ; Tumors of the skin and soft tissue. Premalignant lesions</subject><ispartof>Annals of oncology, 2002-02, Vol.13 (2), p.323-326</ispartof><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13478036$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11886012$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>OMEZZINE, N</creatorcontrib><creatorcontrib>KHOUATRA, C</creatorcontrib><creatorcontrib>LARIVE, S</creatorcontrib><creatorcontrib>FREYER, G</creatorcontrib><creatorcontrib>ISAAC-PINET, S</creatorcontrib><creatorcontrib>GERINIERE, L</creatorcontrib><creatorcontrib>DROZ, J.-P</creatorcontrib><creatorcontrib>SOUQUET, P.-J</creatorcontrib><title>Rhabdomyosarcoma arising in mediastinal teratoma in an adult man: a case report</title><title>Annals of oncology</title><addtitle>Ann Oncol</addtitle><description>We report a case of rhabdomyosarcoma which occurred in a mediastinal teratoma in a 44-year-old man. Presentation symptoms were chest pain, hoarseness and a cough. Diagnosis was fortuitous, performed by the histological and immunohistochemical study of a mediastinal tumour biopsy specimen that showed embryonal carcinoma and yolk sac tumour components associated with the rhabdomyosarcoma. After cisplatin-based chemotherapy (bleomycin-etoposide-cisplatin), surgical resection of the residual mediastinal tumour was performed. Histological and immunohistochemical study of this tumour confirmed the presence of mature teratoma and embryonal rhabdomyosarcoma. Evolution was marked by a local extension of the mediastinal tumour, occurrence of multiple metastases and bone marrow involvement. The patient died 8 months after diagnosis despite chemotherapy and radiotherapy. A review of the literature reveals that the development of rhabdomyosarcoma in primary mediastinal teratomas is unusual in adults. The diagnostic, therapeutic and prognostic implications of such an association are reviewed.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Dermatology</subject><subject>Humans</subject><subject>Male</subject><subject>Mediastinal Neoplasms - complications</subject><subject>Medical sciences</subject><subject>Pneumology</subject><subject>Rhabdomyosarcoma, Embryonal - etiology</subject><subject>Teratoma - complications</subject><subject>Tumors of the respiratory system and mediastinum</subject><subject>Tumors of the skin and soft tissue. Premalignant lesions</subject><issn>0923-7534</issn><issn>1569-8041</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFj81LAzEUxIMotlaPXiUXj2tfkt18eJNSP6BQED2Xt0lWI7vZJdke-t-7YkUYGHjzY3hDyDWDOwZGLDHGPtpl5xrg_ITMWSVNoaFkp2QOhotCVaKckYucvwBAGm7OyYwxrSUwPifb10-sXd8d-ozJ9h1STCGH-EFDpJ13AfMYIrZ09AnHn3y64yS3b0faYbynSC1mT5Mf-jRekrMG2-yvjr4g74_rt9Vzsdk-vaweNsXAhRoLBHRCVwoZl5yD1Vw7b72rPHKvvCu947VUjaqd4FJLAzVUSkldAzNMKLEgN7-9w76e3twNKXSYDru_ZRNwewQwW2ybhNGG_M-JUmkQUnwDm61eEA</recordid><startdate>20020201</startdate><enddate>20020201</enddate><creator>OMEZZINE, N</creator><creator>KHOUATRA, C</creator><creator>LARIVE, S</creator><creator>FREYER, G</creator><creator>ISAAC-PINET, S</creator><creator>GERINIERE, L</creator><creator>DROZ, J.-P</creator><creator>SOUQUET, P.-J</creator><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20020201</creationdate><title>Rhabdomyosarcoma arising in mediastinal teratoma in an adult man: a case report</title><author>OMEZZINE, N ; KHOUATRA, C ; LARIVE, S ; FREYER, G ; ISAAC-PINET, S ; GERINIERE, L ; DROZ, J.-P ; SOUQUET, P.-J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p237t-a0ad3857a126220c828deced5ea2e7ed4ed2b67f7bd3268690b057768b0191373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Dermatology</topic><topic>Humans</topic><topic>Male</topic><topic>Mediastinal Neoplasms - complications</topic><topic>Medical sciences</topic><topic>Pneumology</topic><topic>Rhabdomyosarcoma, Embryonal - etiology</topic><topic>Teratoma - complications</topic><topic>Tumors of the respiratory system and mediastinum</topic><topic>Tumors of the skin and soft tissue. Premalignant lesions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>OMEZZINE, N</creatorcontrib><creatorcontrib>KHOUATRA, C</creatorcontrib><creatorcontrib>LARIVE, S</creatorcontrib><creatorcontrib>FREYER, G</creatorcontrib><creatorcontrib>ISAAC-PINET, S</creatorcontrib><creatorcontrib>GERINIERE, L</creatorcontrib><creatorcontrib>DROZ, J.-P</creatorcontrib><creatorcontrib>SOUQUET, P.-J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Annals of oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>OMEZZINE, N</au><au>KHOUATRA, C</au><au>LARIVE, S</au><au>FREYER, G</au><au>ISAAC-PINET, S</au><au>GERINIERE, L</au><au>DROZ, J.-P</au><au>SOUQUET, P.-J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rhabdomyosarcoma arising in mediastinal teratoma in an adult man: a case report</atitle><jtitle>Annals of oncology</jtitle><addtitle>Ann Oncol</addtitle><date>2002-02-01</date><risdate>2002</risdate><volume>13</volume><issue>2</issue><spage>323</spage><epage>326</epage><pages>323-326</pages><issn>0923-7534</issn><eissn>1569-8041</eissn><abstract>We report a case of rhabdomyosarcoma which occurred in a mediastinal teratoma in a 44-year-old man. Presentation symptoms were chest pain, hoarseness and a cough. Diagnosis was fortuitous, performed by the histological and immunohistochemical study of a mediastinal tumour biopsy specimen that showed embryonal carcinoma and yolk sac tumour components associated with the rhabdomyosarcoma. After cisplatin-based chemotherapy (bleomycin-etoposide-cisplatin), surgical resection of the residual mediastinal tumour was performed. Histological and immunohistochemical study of this tumour confirmed the presence of mature teratoma and embryonal rhabdomyosarcoma. Evolution was marked by a local extension of the mediastinal tumour, occurrence of multiple metastases and bone marrow involvement. The patient died 8 months after diagnosis despite chemotherapy and radiotherapy. A review of the literature reveals that the development of rhabdomyosarcoma in primary mediastinal teratomas is unusual in adults. The diagnostic, therapeutic and prognostic implications of such an association are reviewed.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>11886012</pmid><doi>10.1093/annonc/mdf022</doi><tpages>4</tpages></addata></record> |
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| ispartof | Annals of oncology, 2002-02, Vol.13 (2), p.323-326 |
| issn | 0923-7534 1569-8041 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Biological and medical sciences Dermatology Humans Male Mediastinal Neoplasms - complications Medical sciences Pneumology Rhabdomyosarcoma, Embryonal - etiology Teratoma - complications Tumors of the respiratory system and mediastinum Tumors of the skin and soft tissue. Premalignant lesions |
| title | Rhabdomyosarcoma arising in mediastinal teratoma in an adult man: a case report |
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