Formation of 8-hydroxydeoxyguanosine and cell-cycle arrest in the rat liver via generation of oxidative stress by phenobarbital: association with expression profiles of p21(WAF1/Cip1), cyclin D1 and Ogg1

To evaluate the risk of exposure to so-called non-genotoxic chemicals and elucidate mechanisms underlying their promoting activity on rat liver carcinogenesis the formation of 8-hydroxy-2'-deoxyguanosine (8-OHdG), cytochrome P-450 (P-450) and hydroxyl radicals induction, DNA repair and alterati...

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Veröffentlicht in:	Carcinogenesis (New York) 2002-02, Vol.23 (2), p.341
Hauptverfasser:	Kinoshita, Anna, Wanibuchi, Hideki, Imaoka, Susumu, Ogawa, Motome, Masuda, Chikayoshi, Morimura, Keiichirou, Funae, Yoshihiko, Fukushima, Shoji
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Aryl Hydrocarbon Hydroxylases Carcinogens Cell Cycle Cell Division Cell Nucleus - drug effects Cell Nucleus - enzymology Cyclin D1 - biosynthesis Cyclin-Dependent Kinase Inhibitor p21 Cyclins - biosynthesis Cytochrome P-450 CYP2B1 - biosynthesis Cytochrome P-450 Enzyme System - biosynthesis Cytoplasm - drug effects Cytoplasm - enzymology Deoxyguanosine - analogs & derivatives Deoxyguanosine - chemistry DNA Damage DNA Repair DNA, Single-Stranded - metabolism DNA-Formamidopyrimidine Glycosylase Dose-Response Relationship, Drug Excitatory Amino Acid Antagonists - pharmacology Hepatocytes - drug effects Hepatocytes - enzymology Hydroxyl Radical Immunohistochemistry Liver - drug effects Liver - physiology Male Microsomes, Liver - drug effects Microsomes, Liver - enzymology N-Glycosyl Hydrolases - biosynthesis Oligonucleotide Array Sequence Analysis Oxidative Stress Phenobarbital Rats Rats, Inbred F344 Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Steroid Hydroxylases - biosynthesis Time Factors
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