Vitamin C and quercetin modulate DNA-damaging effect of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)
The effects of natural compounds, vitamin C and quercetin, present in fruits and vegetables, on the DNA damaging activity of a food carcinogen N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) were examined using the comet assay. Vitamin C, at a concentration of 50 microM, inhibited MNNG-induced DNA...
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| Veröffentlicht in: | Plant foods for human nutrition (Dordrecht) 2002, Vol.57 (1), p.53-61 |
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| container_title | Plant foods for human nutrition (Dordrecht) |
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| creator | BŁASIAK, J TRZECIAK, A GASIOROWSKA, A DRZEWOSKI, J MAŁECKA-PANAS, E |
| description | The effects of natural compounds, vitamin C and quercetin, present in fruits and vegetables, on the DNA damaging activity of a food carcinogen N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) were examined using the comet assay. Vitamin C, at a concentration of 50 microM, inhibited MNNG-induced DNA damage in human lymphocytes. Quercetin, up to a concentration of 10 microM, increased the extent of DNA damage, but at concentrations above 10 microM decreased damage below control values. Furthermore, quercetin had a strong antioxidant activity against oxidative damage evoked by H2O2 at 10 microM. The results obtained suggest that vitamin C and quercetin may have anti- or pro-oxidative properties depending on the state of the cell. |
| doi_str_mv | 10.1023/A:1013165718960 |
| format | Article |
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Vitamin C, at a concentration of 50 microM, inhibited MNNG-induced DNA damage in human lymphocytes. Quercetin, up to a concentration of 10 microM, increased the extent of DNA damage, but at concentrations above 10 microM decreased damage below control values. Furthermore, quercetin had a strong antioxidant activity against oxidative damage evoked by H2O2 at 10 microM. The results obtained suggest that vitamin C and quercetin may have anti- or pro-oxidative properties depending on the state of the cell.</description><identifier>ISSN: 0921-9668</identifier><identifier>EISSN: 1573-9104</identifier><identifier>DOI: 10.1023/A:1013165718960</identifier><identifier>PMID: 11855621</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Adult ; Antioxidants - pharmacology ; Ascorbic Acid - pharmacology ; Biological and medical sciences ; Carcinogenesis, carcinogens and anticarcinogens ; Copper - pharmacology ; DNA Damage - drug effects ; Foods and miscellaneous ; Fruit - chemistry ; General pharmacology ; Humans ; Hydrogen Peroxide - pharmacology ; Lymphocytes - chemistry ; Medical sciences ; Methylnitronitrosoguanidine - pharmacology ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. 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Vitamin C, at a concentration of 50 microM, inhibited MNNG-induced DNA damage in human lymphocytes. Quercetin, up to a concentration of 10 microM, increased the extent of DNA damage, but at concentrations above 10 microM decreased damage below control values. Furthermore, quercetin had a strong antioxidant activity against oxidative damage evoked by H2O2 at 10 microM. The results obtained suggest that vitamin C and quercetin may have anti- or pro-oxidative properties depending on the state of the cell.</description><subject>Adult</subject><subject>Antioxidants - pharmacology</subject><subject>Ascorbic Acid - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Carcinogenesis, carcinogens and anticarcinogens</subject><subject>Copper - pharmacology</subject><subject>DNA Damage - drug effects</subject><subject>Foods and miscellaneous</subject><subject>Fruit - chemistry</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Hydrogen Peroxide - pharmacology</subject><subject>Lymphocytes - chemistry</subject><subject>Medical sciences</subject><subject>Methylnitronitrosoguanidine - pharmacology</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. 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Drug treatments</topic><topic>Quercetin - pharmacology</topic><topic>Tumors</topic><topic>Vegetables - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BŁASIAK, J</creatorcontrib><creatorcontrib>TRZECIAK, A</creatorcontrib><creatorcontrib>GASIOROWSKA, A</creatorcontrib><creatorcontrib>DRZEWOSKI, J</creatorcontrib><creatorcontrib>MAŁECKA-PANAS, E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Plant foods for human nutrition (Dordrecht)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BŁASIAK, J</au><au>TRZECIAK, A</au><au>GASIOROWSKA, A</au><au>DRZEWOSKI, J</au><au>MAŁECKA-PANAS, E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin C and quercetin modulate DNA-damaging effect of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)</atitle><jtitle>Plant foods for human nutrition (Dordrecht)</jtitle><addtitle>Plant Foods Hum Nutr</addtitle><date>2002</date><risdate>2002</risdate><volume>57</volume><issue>1</issue><spage>53</spage><epage>61</epage><pages>53-61</pages><issn>0921-9668</issn><eissn>1573-9104</eissn><abstract>The effects of natural compounds, vitamin C and quercetin, present in fruits and vegetables, on the DNA damaging activity of a food carcinogen N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) were examined using the comet assay. Vitamin C, at a concentration of 50 microM, inhibited MNNG-induced DNA damage in human lymphocytes. Quercetin, up to a concentration of 10 microM, increased the extent of DNA damage, but at concentrations above 10 microM decreased damage below control values. Furthermore, quercetin had a strong antioxidant activity against oxidative damage evoked by H2O2 at 10 microM. The results obtained suggest that vitamin C and quercetin may have anti- or pro-oxidative properties depending on the state of the cell.</abstract><cop>Heidelberg</cop><pub>Springer</pub><pmid>11855621</pmid><doi>10.1023/A:1013165718960</doi><tpages>9</tpages></addata></record> |
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| ispartof | Plant foods for human nutrition (Dordrecht), 2002, Vol.57 (1), p.53-61 |
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| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adult Antioxidants - pharmacology Ascorbic Acid - pharmacology Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Copper - pharmacology DNA Damage - drug effects Foods and miscellaneous Fruit - chemistry General pharmacology Humans Hydrogen Peroxide - pharmacology Lymphocytes - chemistry Medical sciences Methylnitronitrosoguanidine - pharmacology Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Quercetin - pharmacology Tumors Vegetables - chemistry |
| title | Vitamin C and quercetin modulate DNA-damaging effect of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) |
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