Sevoflurane vs. isoflurane: a clinical comparison in day surgery

Discharge times after ambulatory surgery are determined by postoperative complications and in particular by the presence and severity of nausea and vomiting. Sevoflurane has become a popular agent for day-case surgery despite little evidence of clear advantages over current alternatives. We compared...

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Veröffentlicht in:Anaesthesia 2002, Vol.57 (1), p.52-56
Hauptverfasser: ELCOCK, D. H, SWEENEY, B. P
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description Discharge times after ambulatory surgery are determined by postoperative complications and in particular by the presence and severity of nausea and vomiting. Sevoflurane has become a popular agent for day-case surgery despite little evidence of clear advantages over current alternatives. We compared this agent with isoflurane in day-case patients undergoing knee arthroscopy in order to quantify the incidence of complications associated with each agent. One hundred and eighty patients received a standardised anaesthetic induction with propofol and fentanyl followed by maintenance with either isoflurane or sevoflurane. Standardised postoperative analgesic and anti-emetic drugs were prescribed. Any intra-operative cardiovascular or respiratory instability was recorded. After surgery, nausea, vomiting and pain were assessed. Almost all patients made an uneventful recovery and were discharged as scheduled. There was a significantly higher incidence of complications in the sevoflurane group. These included the presence of nausea and vomiting, and cardiovascular and respiratory complications. We found nothing to commend the routine use of sevoflurane rather than isoflurane in the context of day case anaesthesia.
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source MEDLINE; Access via Wiley Online Library; EZB-FREE-00999 freely available EZB journals; Wiley Online Library (Open Access Collection)
subjects Adolescent
Adult
Aged
Aged, 80 and over
Ambulatory Surgical Procedures
Anesthetics, Inhalation - adverse effects
Anesthetics. Neuromuscular blocking agents
Antiemetics - therapeutic use
Arthroscopy
Biological and medical sciences
Cardiovascular Diseases - chemically induced
Female
Humans
Isoflurane - adverse effects
Knee Joint - surgery
Male
Medical sciences
Methyl Ethers - adverse effects
Middle Aged
Neuropharmacology
Pain, Postoperative - prevention & control
Pharmacology. Drug treatments
Postoperative Nausea and Vomiting - chemically induced
Postoperative Nausea and Vomiting - drug therapy
Respiration Disorders - chemically induced
Sevoflurane
title Sevoflurane vs. isoflurane: a clinical comparison in day surgery
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