Tibolone and 5alpha-dihydrotestosterone alone or in combination with an antiandrogen in a rat breast tumour model

Tibolone was combined with the antiandrogen flutamide to determine whether the inhibition of tumour growth in the prophylactic 7,12-dimethylbenz(a)anthracene (DMBA) rat model could be attributed to androgenic properties of one of its metabolites. The mean tumour load after tibolone (0.25 or 1.0 mg/k...

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Veröffentlicht in:	European journal of cancer (1990) 2002-02, Vol.38 (3), p.443
Hauptverfasser:	Deckers, G H, Verheul, H A M, van Aalst, G B T, Cremers, E A M, de Gooyer, M E, Kloosterboer, H J
Format:	Artikel
Sprache:	eng
Schlagworte:	9,10-Dimethyl-1,2-benzanthracene - administration & dosage Administration, Oral Animals Antineoplastic Agents, Hormonal - administration & dosage Antineoplastic Combined Chemotherapy Protocols - therapeutic use Female Flutamide - administration & dosage Norpregnenes - administration & dosage Rats Rats, Sprague-Dawley
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