Antitumor Activity of Fibroblast Growth Factors (FGFs) for Medulloblastoma May Correlate with FGF Receptor Expression and Tumor Variant

Members of the fibroblast growth factor (FGF) family, which normally control cerebellar neuronal maturation, may represent more natural and less toxic tools with which to target medulloblastoma (MB), an embryonal brain tumor thought to arise from cerebellar neuronal precursors. In support of this, w...

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Veröffentlicht in:	Clinical cancer research 2002-01, Vol.8 (1), p.246-257
Hauptverfasser:	DUPLAN, Sabine M, THEORET, Yves, KENIGSBERG, Rhoda L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antineoplastic Agents - therapeutic use bcl-2-Associated X Protein bcl-X Protein Biological and medical sciences Blotting, Western Brain Neoplasms - drug therapy Brain Neoplasms - metabolism Brain Neoplasms - pathology Cell Differentiation - physiology Cell Survival Chemotherapy Child, Preschool Fibroblast Growth Factor 2 - therapeutic use Fibroblast Growth Factor 9 Fibroblast Growth Factors - therapeutic use Humans Male Medical sciences Medulloblastoma - drug therapy Medulloblastoma - metabolism Medulloblastoma - pathology Neurites - drug effects Pharmacology. Drug treatments Precipitin Tests Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-bcl-2 - metabolism Receptors, Fibroblast Growth Factor - metabolism Tumor Cells, Cultured - drug effects Tumor Cells, Cultured - metabolism
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