Intestinal alkalization as a possible preventive mechanism in irinotecan (CPT-11)-induced diarrhea

The therapeutic efficacy of irinotecan (CPT-11), a DNA topoisomerase inhibitor, is often limited by the induction of severe late-onset diarrhea. This prodrug and its active metabolite, 7-ethyl-10-hydroxy-camptothecin (SN-38), have a labile alpha-hydroxy-lactone ring that undergoes pH-dependent rever...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2002, Vol.62 (1), p.179-187
Hauptverfasser:	IKEGAMI, Tadashi, LINAN HA, ARIMORI, Kazuhiko, LATHAM, Patricia, KOBAYASHI, Kunihiko, CERYAK, Susan, MATSUZAKI, Yasushi, BOUSCAREL, Bernard
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents, Phytogenic - adverse effects Antineoplastic Agents, Phytogenic - pharmacokinetics Apoptosis - drug effects Biological and medical sciences Camptothecin - adverse effects Camptothecin - analogs & derivatives Camptothecin - pharmacokinetics Carboxylic Acids - adverse effects Carboxylic Acids - pharmacokinetics Cell Cycle - drug effects Cell Division - drug effects Cricetinae Diarrhea - chemically induced Diarrhea - prevention & control Drug toxicity and drugs side effects treatment Glucuronides - adverse effects Glucuronides - pharmacokinetics HT29 Cells - drug effects HT29 Cells - metabolism Humans Hydrogen-Ion Concentration Intestines - cytology Intestines - drug effects Intestines - metabolism Lactones - adverse effects Lactones - pharmacokinetics Male Medical sciences Mesocricetus Pharmacology. Drug treatments Sodium Bicarbonate - pharmacology Toxicity: digestive system
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