Synthesis and anticonvulsant activity of N,N-phthaloyl derivatives of central nervous system inhibitory amino acids

In order to study the influence of the length of the amino acid chain of N,N‐phthaloylamino acid amides as analogues of the former anticonvulsant taltrimide on the seizureantagonizing activity glycine, β‐alanine and γ‐aminobutyric acid (GABA) derivatives were synthesized. The corresponding taurine d...

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Veröffentlicht in:	Archiv der Pharmazie (Weinheim) 2001-10, Vol.334 (10), p.323-331
Hauptverfasser:	Usifoh, Cyril O., Lambert, Didier M., Wouters, Johan, Scriba, Gerhard K. E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - chemical synthesis Amino Acids - pharmacology Animals Anticonvulsants Anticonvulsants - chemical synthesis Anticonvulsants - pharmacology Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Chemical Phenomena Chemistry, Physical Convulsants - pharmacology Electroshock Glycine Indicators and Reagents Medical sciences Mice N, N‐Phthaloylamino acids N-Phthaloylamino acids Neuropharmacology Pentylenetetrazole - antagonists & inhibitors Pentylenetetrazole - pharmacology Pharmacology. Drug treatments Phthalic Acids - chemical synthesis Phthalic Acids - pharmacology Structure-Activity Relationship β-Alanine γ-Aminobutyric acid
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