Antimutagenic activity against trp-p-1 of the edible Thai plant, Oroxylum indicum Vent
A methanolic extract of Oroxylum indicum strongly inhibited the mutagenicity of Trp-P-1 in an Ames test. The major antimutagenic constituent was identified as baicalein with an IC sub50 value of 2.78+-0.15microM. The potent antimutagenicity of the extract was correlated with the high content (3.95+-...
Gespeichert in:
| Veröffentlicht in: | Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2001-10, Vol.65 (10), p.2358-2360 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2360 |
|---|---|
| container_issue | 10 |
| container_start_page | 2358 |
| container_title | Bioscience, biotechnology, and biochemistry |
| container_volume | 65 |
| creator | Nakahara, K. (Japan International Research Center for Agricultural Sciences, Tsukuba, Ibaraki) Onishi Kameyama, M Ono, H Yoshida, M Trakoontivakorn, G |
| description | A methanolic extract of Oroxylum indicum strongly inhibited the mutagenicity of Trp-P-1 in an Ames test. The major antimutagenic constituent was identified as baicalein with an IC sub50 value of 2.78+-0.15microM. The potent antimutagenicity of the extract was correlated with the high content (3.95+-0.43%, dry weight) of baicalein. Baicalein acted as a desmutagen since it inhibited the N-hydroxylation of Trp-P-2. |
| doi_str_mv | 10.1271/bbb.65.2358 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_pasca</sourceid><recordid>TN_cdi_pubmed_primary_11758941</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>11758941</sourcerecordid><originalsourceid>FETCH-LOGICAL-f385t-972645b6afe43ff8db0eda93753f61b273c38604fc491990151664388874ddb03</originalsourceid><addsrcrecordid>eNpF0E1LAzEQBuAgiq3Vk2clF29uTTbfx1L8pFAPtdcy2U3ayO522U2L_fcGWhEGXhgehplB6JaSMc0VfbLWjqUY50zoMzSkjKtMGq7O0ZAYKjPNBR2gq77_JiQ1BL1EA0qV0IbTIVpOmhjqXYS1a0KBoYhhH-IBwxpC00ccuzZrM4q3HseNw64MtnJ4sYGA2wqa-Ijn3fbnUO1qHJoyFCmXronX6MJD1bubU47Q18vzYvqWzeav79PJLPNMi5gZlUsurATvOPNel5a4EgxTgnlJba5YwbQk3BfcUGNI2l5KzrTWipcJsxG6P85td7Z25artQg3dYfV3YAIPJwB9AZXvoClC_-8Yp4SxPLm7o_OwXcG6S-bjMyckFUt_Y78RqmZW</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Antimutagenic activity against trp-p-1 of the edible Thai plant, Oroxylum indicum Vent</title><source>J-STAGE Free</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>Freely Accessible Japanese Titles</source><source>Free Full-Text Journals in Chemistry</source><creator>Nakahara, K. (Japan International Research Center for Agricultural Sciences, Tsukuba, Ibaraki) ; Onishi Kameyama, M ; Ono, H ; Yoshida, M ; Trakoontivakorn, G</creator><creatorcontrib>Nakahara, K. (Japan International Research Center for Agricultural Sciences, Tsukuba, Ibaraki) ; Onishi Kameyama, M ; Ono, H ; Yoshida, M ; Trakoontivakorn, G</creatorcontrib><description>A methanolic extract of Oroxylum indicum strongly inhibited the mutagenicity of Trp-P-1 in an Ames test. The major antimutagenic constituent was identified as baicalein with an IC sub50 value of 2.78+-0.15microM. The potent antimutagenicity of the extract was correlated with the high content (3.95+-0.43%, dry weight) of baicalein. Baicalein acted as a desmutagen since it inhibited the N-hydroxylation of Trp-P-2.</description><identifier>ISSN: 0916-8451</identifier><identifier>EISSN: 1347-6947</identifier><identifier>DOI: 10.1271/bbb.65.2358</identifier><identifier>PMID: 11758941</identifier><language>eng</language><publisher>Tokyo: Japan Society for Bioscience Biotechnology and Agrochemistry</publisher><subject>Antimutagenic Agents - chemistry ; Antimutagenic Agents - isolation & purification ; Antimutagenic Agents - pharmacology ; ANTIMUTAGENS ; BIGNONIACEAE ; Biological and medical sciences ; Carbolines - antagonists & inhibitors ; Chemical mutagenesis ; Chromatography, High Pressure Liquid ; EXTRACTS ; Flavanones ; FLAVONOIDS ; Flavonoids - chemistry ; Flavonoids - isolation & purification ; Fruit ; Inhibitory Concentration 50 ; Magnetic Resonance Spectroscopy ; Medical sciences ; MUTAGENICITY ; Mutagenicity Tests ; Mutagens ; Plant Extracts ; Plants, Edible - chemistry ; Spectrophotometry, Ultraviolet ; Thailand ; Toxicology</subject><ispartof>Bioscience, biotechnology, and biochemistry, 2001-10, Vol.65 (10), p.2358-2360</ispartof><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13410332$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11758941$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nakahara, K. (Japan International Research Center for Agricultural Sciences, Tsukuba, Ibaraki)</creatorcontrib><creatorcontrib>Onishi Kameyama, M</creatorcontrib><creatorcontrib>Ono, H</creatorcontrib><creatorcontrib>Yoshida, M</creatorcontrib><creatorcontrib>Trakoontivakorn, G</creatorcontrib><title>Antimutagenic activity against trp-p-1 of the edible Thai plant, Oroxylum indicum Vent</title><title>Bioscience, biotechnology, and biochemistry</title><addtitle>Biosci Biotechnol Biochem</addtitle><description>A methanolic extract of Oroxylum indicum strongly inhibited the mutagenicity of Trp-P-1 in an Ames test. The major antimutagenic constituent was identified as baicalein with an IC sub50 value of 2.78+-0.15microM. The potent antimutagenicity of the extract was correlated with the high content (3.95+-0.43%, dry weight) of baicalein. Baicalein acted as a desmutagen since it inhibited the N-hydroxylation of Trp-P-2.</description><subject>Antimutagenic Agents - chemistry</subject><subject>Antimutagenic Agents - isolation & purification</subject><subject>Antimutagenic Agents - pharmacology</subject><subject>ANTIMUTAGENS</subject><subject>BIGNONIACEAE</subject><subject>Biological and medical sciences</subject><subject>Carbolines - antagonists & inhibitors</subject><subject>Chemical mutagenesis</subject><subject>Chromatography, High Pressure Liquid</subject><subject>EXTRACTS</subject><subject>Flavanones</subject><subject>FLAVONOIDS</subject><subject>Flavonoids - chemistry</subject><subject>Flavonoids - isolation & purification</subject><subject>Fruit</subject><subject>Inhibitory Concentration 50</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Medical sciences</subject><subject>MUTAGENICITY</subject><subject>Mutagenicity Tests</subject><subject>Mutagens</subject><subject>Plant Extracts</subject><subject>Plants, Edible - chemistry</subject><subject>Spectrophotometry, Ultraviolet</subject><subject>Thailand</subject><subject>Toxicology</subject><issn>0916-8451</issn><issn>1347-6947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0E1LAzEQBuAgiq3Vk2clF29uTTbfx1L8pFAPtdcy2U3ayO522U2L_fcGWhEGXhgehplB6JaSMc0VfbLWjqUY50zoMzSkjKtMGq7O0ZAYKjPNBR2gq77_JiQ1BL1EA0qV0IbTIVpOmhjqXYS1a0KBoYhhH-IBwxpC00ccuzZrM4q3HseNw64MtnJ4sYGA2wqa-Ijn3fbnUO1qHJoyFCmXronX6MJD1bubU47Q18vzYvqWzeav79PJLPNMi5gZlUsurATvOPNel5a4EgxTgnlJba5YwbQk3BfcUGNI2l5KzrTWipcJsxG6P85td7Z25artQg3dYfV3YAIPJwB9AZXvoClC_-8Yp4SxPLm7o_OwXcG6S-bjMyckFUt_Y78RqmZW</recordid><startdate>20011001</startdate><enddate>20011001</enddate><creator>Nakahara, K. (Japan International Research Center for Agricultural Sciences, Tsukuba, Ibaraki)</creator><creator>Onishi Kameyama, M</creator><creator>Ono, H</creator><creator>Yoshida, M</creator><creator>Trakoontivakorn, G</creator><general>Japan Society for Bioscience Biotechnology and Agrochemistry</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20011001</creationdate><title>Antimutagenic activity against trp-p-1 of the edible Thai plant, Oroxylum indicum Vent</title><author>Nakahara, K. (Japan International Research Center for Agricultural Sciences, Tsukuba, Ibaraki) ; Onishi Kameyama, M ; Ono, H ; Yoshida, M ; Trakoontivakorn, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-f385t-972645b6afe43ff8db0eda93753f61b273c38604fc491990151664388874ddb03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Antimutagenic Agents - chemistry</topic><topic>Antimutagenic Agents - isolation & purification</topic><topic>Antimutagenic Agents - pharmacology</topic><topic>ANTIMUTAGENS</topic><topic>BIGNONIACEAE</topic><topic>Biological and medical sciences</topic><topic>Carbolines - antagonists & inhibitors</topic><topic>Chemical mutagenesis</topic><topic>Chromatography, High Pressure Liquid</topic><topic>EXTRACTS</topic><topic>Flavanones</topic><topic>FLAVONOIDS</topic><topic>Flavonoids - chemistry</topic><topic>Flavonoids - isolation & purification</topic><topic>Fruit</topic><topic>Inhibitory Concentration 50</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Medical sciences</topic><topic>MUTAGENICITY</topic><topic>Mutagenicity Tests</topic><topic>Mutagens</topic><topic>Plant Extracts</topic><topic>Plants, Edible - chemistry</topic><topic>Spectrophotometry, Ultraviolet</topic><topic>Thailand</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakahara, K. (Japan International Research Center for Agricultural Sciences, Tsukuba, Ibaraki)</creatorcontrib><creatorcontrib>Onishi Kameyama, M</creatorcontrib><creatorcontrib>Ono, H</creatorcontrib><creatorcontrib>Yoshida, M</creatorcontrib><creatorcontrib>Trakoontivakorn, G</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Bioscience, biotechnology, and biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakahara, K. (Japan International Research Center for Agricultural Sciences, Tsukuba, Ibaraki)</au><au>Onishi Kameyama, M</au><au>Ono, H</au><au>Yoshida, M</au><au>Trakoontivakorn, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antimutagenic activity against trp-p-1 of the edible Thai plant, Oroxylum indicum Vent</atitle><jtitle>Bioscience, biotechnology, and biochemistry</jtitle><addtitle>Biosci Biotechnol Biochem</addtitle><date>2001-10-01</date><risdate>2001</risdate><volume>65</volume><issue>10</issue><spage>2358</spage><epage>2360</epage><pages>2358-2360</pages><issn>0916-8451</issn><eissn>1347-6947</eissn><abstract>A methanolic extract of Oroxylum indicum strongly inhibited the mutagenicity of Trp-P-1 in an Ames test. The major antimutagenic constituent was identified as baicalein with an IC sub50 value of 2.78+-0.15microM. The potent antimutagenicity of the extract was correlated with the high content (3.95+-0.43%, dry weight) of baicalein. Baicalein acted as a desmutagen since it inhibited the N-hydroxylation of Trp-P-2.</abstract><cop>Tokyo</cop><pub>Japan Society for Bioscience Biotechnology and Agrochemistry</pub><pmid>11758941</pmid><doi>10.1271/bbb.65.2358</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0916-8451 |
| ispartof | Bioscience, biotechnology, and biochemistry, 2001-10, Vol.65 (10), p.2358-2360 |
| issn | 0916-8451 1347-6947 |
| language | eng |
| recordid | cdi_pubmed_primary_11758941 |
| source | J-STAGE Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); Freely Accessible Japanese Titles; Free Full-Text Journals in Chemistry |
| subjects | Antimutagenic Agents - chemistry Antimutagenic Agents - isolation & purification Antimutagenic Agents - pharmacology ANTIMUTAGENS BIGNONIACEAE Biological and medical sciences Carbolines - antagonists & inhibitors Chemical mutagenesis Chromatography, High Pressure Liquid EXTRACTS Flavanones FLAVONOIDS Flavonoids - chemistry Flavonoids - isolation & purification Fruit Inhibitory Concentration 50 Magnetic Resonance Spectroscopy Medical sciences MUTAGENICITY Mutagenicity Tests Mutagens Plant Extracts Plants, Edible - chemistry Spectrophotometry, Ultraviolet Thailand Toxicology |
| title | Antimutagenic activity against trp-p-1 of the edible Thai plant, Oroxylum indicum Vent |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T09%3A24%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_pasca&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Antimutagenic%20activity%20against%20trp-p-1%20of%20the%20edible%20Thai%20plant,%20Oroxylum%20indicum%20Vent&rft.jtitle=Bioscience,%20biotechnology,%20and%20biochemistry&rft.au=Nakahara,%20K.%20(Japan%20International%20Research%20Center%20for%20Agricultural%20Sciences,%20Tsukuba,%20Ibaraki)&rft.date=2001-10-01&rft.volume=65&rft.issue=10&rft.spage=2358&rft.epage=2360&rft.pages=2358-2360&rft.issn=0916-8451&rft.eissn=1347-6947&rft_id=info:doi/10.1271/bbb.65.2358&rft_dat=%3Cpubmed_pasca%3E11758941%3C/pubmed_pasca%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/11758941&rfr_iscdi=true |