Stereoselectivities of enantiomers of huperzine A in protection against beta-amyloid(25-35)-induced injury in PC12 and NG108-15 cells and cholinesterase inhibition in mice

Recently, the potent cholinesterase inhibitor (-)-huperzine A (HupA) was demonstrated to protect neuronal and glial cells against the cytotoxicity of beta-amyloid (Abeta). Since the unnatural (+)-HupA is a much less potent inhibitor, it was of interest to examine the stereoselectivity of cellular pr...

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Veröffentlicht in:	Neuroscience letters 2002-01, Vol.317 (3), p.143
Hauptverfasser:	Zhang, Hai Yan, Liang, Yan Qi, Tang, Xi Can, He, Xu Chang, Bai, Dong Lu
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - metabolism Alkaloids Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Alzheimer Disease - physiopathology Amyloid beta-Peptides - antagonists & inhibitors Amyloid beta-Peptides - metabolism Animals Cerebral Cortex - drug effects Cerebral Cortex - metabolism Cerebral Cortex - physiopathology Cholinesterase Inhibitors - pharmacology Dose-Response Relationship, Drug Mice Neurons - drug effects Neurons - metabolism Neuroprotective Agents - pharmacology Neurotoxins - antagonists & inhibitors Neurotoxins - metabolism PC12 Cells Peptide Fragments - antagonists & inhibitors Peptide Fragments - metabolism Rats Sesquiterpenes - chemistry Sesquiterpenes - pharmacology Stereoisomerism
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