Muscarine Reduces Calcium-Dependent Electrical Activity in Substantia Nigra Dopaminergic Neurons
1 Department of Anatomy and Neurobiology, Health Science Center, University of Tennessee, Memphis, Tennessee 38163; and 2 Morehouse School of Medicine, Neuroscience Institute, Atlanta, Georgia 30310 Scroggs, Reese S., Carla G. Cardenas, Joseph A. Whittaker, and Stephen T. Kitai. Muscarine Reduce...
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| Veröffentlicht in: | Journal of neurophysiology 2001-12, Vol.86 (6), p.2966-2972 |
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| creator | Scroggs, Reese S Cardenas, Carla G Whittaker, Joseph A Kitai, Stephen T |
| description | 1 Department of Anatomy and Neurobiology,
Health Science Center, University of Tennessee, Memphis, Tennessee
38163; and 2 Morehouse School of Medicine,
Neuroscience Institute, Atlanta, Georgia 30310
Scroggs, Reese S.,
Carla G. Cardenas,
Joseph A. Whittaker, and
Stephen T. Kitai.
Muscarine Reduces Calcium-Dependent Electrical Activity in
Substantia Nigra Dopaminergic Neurons. J. Neurophysiol. 86: 2966-2972, 2001. The effect of muscarine on
Ca 2+ dependent electrical activity was studied in
dopamine (DA) neurons located in the substantia nigra pars compacta
(SNc) in brain slices from young rats, using sharp electrodes. In most
DA neurons tested, muscarine (50 µM) reduced the amplitude of
spontaneous oscillatory potentials and evoked
Ca 2+ -dependent potentials recorded in the
presence of TTX. Muscarine also reduced the amplitude of the slow
afterhyperpolarization (sAHP) following action potentials in most DA
neurons. These data suggest that muscarine reduces
Ca 2+ entry in SNc DA neurons. The reduction of
the amplitude of the sAHP by muscarine in DA neurons may facilitate
bursting initiated by glutamatergic input by increasing the frequency
at which DA neurons can fire. The reduction of the sAHP via activation
of muscarinic receptors in vivo may provide a mechanism whereby
cholinergic inputs to DA neurons from the tegmental peduncular pontine
nucleus could modulate dopamine release at dopaminergic targets in the brain. |
| doi_str_mv | 10.1152/jn.2001.86.6.2966 |
| format | Article |
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Health Science Center, University of Tennessee, Memphis, Tennessee
38163; and 2 Morehouse School of Medicine,
Neuroscience Institute, Atlanta, Georgia 30310
Scroggs, Reese S.,
Carla G. Cardenas,
Joseph A. Whittaker, and
Stephen T. Kitai.
Muscarine Reduces Calcium-Dependent Electrical Activity in
Substantia Nigra Dopaminergic Neurons. J. Neurophysiol. 86: 2966-2972, 2001. The effect of muscarine on
Ca 2+ dependent electrical activity was studied in
dopamine (DA) neurons located in the substantia nigra pars compacta
(SNc) in brain slices from young rats, using sharp electrodes. In most
DA neurons tested, muscarine (50 µM) reduced the amplitude of
spontaneous oscillatory potentials and evoked
Ca 2+ -dependent potentials recorded in the
presence of TTX. Muscarine also reduced the amplitude of the slow
afterhyperpolarization (sAHP) following action potentials in most DA
neurons. These data suggest that muscarine reduces
Ca 2+ entry in SNc DA neurons. The reduction of
the amplitude of the sAHP by muscarine in DA neurons may facilitate
bursting initiated by glutamatergic input by increasing the frequency
at which DA neurons can fire. The reduction of the sAHP via activation
of muscarinic receptors in vivo may provide a mechanism whereby
cholinergic inputs to DA neurons from the tegmental peduncular pontine
nucleus could modulate dopamine release at dopaminergic targets in the brain.</description><identifier>ISSN: 0022-3077</identifier><identifier>EISSN: 1522-1598</identifier><identifier>DOI: 10.1152/jn.2001.86.6.2966</identifier><identifier>PMID: 11731553</identifier><language>eng</language><publisher>United States: Am Phys Soc</publisher><subject>Action Potentials - drug effects ; Animals ; Calcium - physiology ; Dopamine - physiology ; Electrophysiology ; Evoked Potentials - drug effects ; Excitatory Postsynaptic Potentials - drug effects ; In Vitro Techniques ; Male ; Manganese - pharmacology ; muscarine ; Muscarine - pharmacology ; Muscarinic Agonists - pharmacology ; Neurons - drug effects ; Potassium Channels, Calcium-Activated - drug effects ; Rats ; Rats, Sprague-Dawley ; Substantia Nigra - cytology ; Substantia Nigra - drug effects ; Substantia Nigra - physiology ; Tetrodotoxin - pharmacology</subject><ispartof>Journal of neurophysiology, 2001-12, Vol.86 (6), p.2966-2972</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-7e318751256088327b0384da15a4dc0d44e34e10a28b771cd092ecafd2f41ebd3</citedby><cites>FETCH-LOGICAL-c470t-7e318751256088327b0384da15a4dc0d44e34e10a28b771cd092ecafd2f41ebd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,3026,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11731553$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Scroggs, Reese S</creatorcontrib><creatorcontrib>Cardenas, Carla G</creatorcontrib><creatorcontrib>Whittaker, Joseph A</creatorcontrib><creatorcontrib>Kitai, Stephen T</creatorcontrib><title>Muscarine Reduces Calcium-Dependent Electrical Activity in Substantia Nigra Dopaminergic Neurons</title><title>Journal of neurophysiology</title><addtitle>J Neurophysiol</addtitle><description> 1 Department of Anatomy and Neurobiology,
Health Science Center, University of Tennessee, Memphis, Tennessee
38163; and 2 Morehouse School of Medicine,
Neuroscience Institute, Atlanta, Georgia 30310
Scroggs, Reese S.,
Carla G. Cardenas,
Joseph A. Whittaker, and
Stephen T. Kitai.
Muscarine Reduces Calcium-Dependent Electrical Activity in
Substantia Nigra Dopaminergic Neurons. J. Neurophysiol. 86: 2966-2972, 2001. The effect of muscarine on
Ca 2+ dependent electrical activity was studied in
dopamine (DA) neurons located in the substantia nigra pars compacta
(SNc) in brain slices from young rats, using sharp electrodes. In most
DA neurons tested, muscarine (50 µM) reduced the amplitude of
spontaneous oscillatory potentials and evoked
Ca 2+ -dependent potentials recorded in the
presence of TTX. Muscarine also reduced the amplitude of the slow
afterhyperpolarization (sAHP) following action potentials in most DA
neurons. These data suggest that muscarine reduces
Ca 2+ entry in SNc DA neurons. The reduction of
the amplitude of the sAHP by muscarine in DA neurons may facilitate
bursting initiated by glutamatergic input by increasing the frequency
at which DA neurons can fire. The reduction of the sAHP via activation
of muscarinic receptors in vivo may provide a mechanism whereby
cholinergic inputs to DA neurons from the tegmental peduncular pontine
nucleus could modulate dopamine release at dopaminergic targets in the brain.</description><subject>Action Potentials - drug effects</subject><subject>Animals</subject><subject>Calcium - physiology</subject><subject>Dopamine - physiology</subject><subject>Electrophysiology</subject><subject>Evoked Potentials - drug effects</subject><subject>Excitatory Postsynaptic Potentials - drug effects</subject><subject>In Vitro Techniques</subject><subject>Male</subject><subject>Manganese - pharmacology</subject><subject>muscarine</subject><subject>Muscarine - pharmacology</subject><subject>Muscarinic Agonists - pharmacology</subject><subject>Neurons - drug effects</subject><subject>Potassium Channels, Calcium-Activated - drug effects</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Substantia Nigra - cytology</subject><subject>Substantia Nigra - drug effects</subject><subject>Substantia Nigra - physiology</subject><subject>Tetrodotoxin - pharmacology</subject><issn>0022-3077</issn><issn>1522-1598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1v1DAQhi0EokvhB3BBOcEpwR9J7D1W2xaQSpGgnI1jT3a9cpzgD2D_PV7tip44zWj0vI9GL0KvCW4I6ej7vW8oxqQRfdM3dN33T9Cq3GlNurV4ilYYl51hzi_Qixj3GGPeYfocXRDCGek6tkI_PueoVbAeqq9gsoZYbZTTNk_1NSzgDfhU3TjQKVitXHWlk_1l06GyvvqWh5iUT1ZV93YbVHU9L2oqqrC1urqHHGYfX6Jno3IRXp3nJfp-e_Ow-VjfffnwaXN1V-uW41RzYETwjtCux0IwygfMRGsU6VRrNDZtC6wFghUVA-dEG7ymoNVo6NgSGAy7RG9P3iXMPzPEJCcbNTinPMw5SiIoXgvaFpCcQB3mGAOMcgl2UuEgCZbHWuXey2OtUvSyl8daS-bNWZ6HCcxj4txjAdgJ2Nnt7rcNIJfdIdrZzduDvM3OPcCfVMT_lHIxY0m9-3-qfPH4wF90z5Sf</recordid><startdate>20011201</startdate><enddate>20011201</enddate><creator>Scroggs, Reese S</creator><creator>Cardenas, Carla G</creator><creator>Whittaker, Joseph A</creator><creator>Kitai, Stephen T</creator><general>Am Phys Soc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope></search><sort><creationdate>20011201</creationdate><title>Muscarine Reduces Calcium-Dependent Electrical Activity in Substantia Nigra Dopaminergic Neurons</title><author>Scroggs, Reese S ; Cardenas, Carla G ; Whittaker, Joseph A ; Kitai, Stephen T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-7e318751256088327b0384da15a4dc0d44e34e10a28b771cd092ecafd2f41ebd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Action Potentials - drug effects</topic><topic>Animals</topic><topic>Calcium - physiology</topic><topic>Dopamine - physiology</topic><topic>Electrophysiology</topic><topic>Evoked Potentials - drug effects</topic><topic>Excitatory Postsynaptic Potentials - drug effects</topic><topic>In Vitro Techniques</topic><topic>Male</topic><topic>Manganese - pharmacology</topic><topic>muscarine</topic><topic>Muscarine - pharmacology</topic><topic>Muscarinic Agonists - pharmacology</topic><topic>Neurons - drug effects</topic><topic>Potassium Channels, Calcium-Activated - drug effects</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Substantia Nigra - cytology</topic><topic>Substantia Nigra - drug effects</topic><topic>Substantia Nigra - physiology</topic><topic>Tetrodotoxin - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Scroggs, Reese S</creatorcontrib><creatorcontrib>Cardenas, Carla G</creatorcontrib><creatorcontrib>Whittaker, Joseph A</creatorcontrib><creatorcontrib>Kitai, Stephen T</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><jtitle>Journal of neurophysiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Scroggs, Reese S</au><au>Cardenas, Carla G</au><au>Whittaker, Joseph A</au><au>Kitai, Stephen T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Muscarine Reduces Calcium-Dependent Electrical Activity in Substantia Nigra Dopaminergic Neurons</atitle><jtitle>Journal of neurophysiology</jtitle><addtitle>J Neurophysiol</addtitle><date>2001-12-01</date><risdate>2001</risdate><volume>86</volume><issue>6</issue><spage>2966</spage><epage>2972</epage><pages>2966-2972</pages><issn>0022-3077</issn><eissn>1522-1598</eissn><abstract> 1 Department of Anatomy and Neurobiology,
Health Science Center, University of Tennessee, Memphis, Tennessee
38163; and 2 Morehouse School of Medicine,
Neuroscience Institute, Atlanta, Georgia 30310
Scroggs, Reese S.,
Carla G. Cardenas,
Joseph A. Whittaker, and
Stephen T. Kitai.
Muscarine Reduces Calcium-Dependent Electrical Activity in
Substantia Nigra Dopaminergic Neurons. J. Neurophysiol. 86: 2966-2972, 2001. The effect of muscarine on
Ca 2+ dependent electrical activity was studied in
dopamine (DA) neurons located in the substantia nigra pars compacta
(SNc) in brain slices from young rats, using sharp electrodes. In most
DA neurons tested, muscarine (50 µM) reduced the amplitude of
spontaneous oscillatory potentials and evoked
Ca 2+ -dependent potentials recorded in the
presence of TTX. Muscarine also reduced the amplitude of the slow
afterhyperpolarization (sAHP) following action potentials in most DA
neurons. These data suggest that muscarine reduces
Ca 2+ entry in SNc DA neurons. The reduction of
the amplitude of the sAHP by muscarine in DA neurons may facilitate
bursting initiated by glutamatergic input by increasing the frequency
at which DA neurons can fire. The reduction of the sAHP via activation
of muscarinic receptors in vivo may provide a mechanism whereby
cholinergic inputs to DA neurons from the tegmental peduncular pontine
nucleus could modulate dopamine release at dopaminergic targets in the brain.</abstract><cop>United States</cop><pub>Am Phys Soc</pub><pmid>11731553</pmid><doi>10.1152/jn.2001.86.6.2966</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Action Potentials - drug effects Animals Calcium - physiology Dopamine - physiology Electrophysiology Evoked Potentials - drug effects Excitatory Postsynaptic Potentials - drug effects In Vitro Techniques Male Manganese - pharmacology muscarine Muscarine - pharmacology Muscarinic Agonists - pharmacology Neurons - drug effects Potassium Channels, Calcium-Activated - drug effects Rats Rats, Sprague-Dawley Substantia Nigra - cytology Substantia Nigra - drug effects Substantia Nigra - physiology Tetrodotoxin - pharmacology |
| title | Muscarine Reduces Calcium-Dependent Electrical Activity in Substantia Nigra Dopaminergic Neurons |
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