Development and degeneration of dorsal root ganglia in the absence of the HMG-domain transcription factor Sox10
The HMG-domain transcription factor Sox10 is essential for the development of various neural crest derived lineages including glia and neurons of the peripheral nervous system (PNS). Within the PNS the most striking defect is the complete absence of glial differentiation whereas neurogenesis seemed...
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| Veröffentlicht in: | Mechanisms of development 2001-12, Vol.109 (2), p.253 |
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| creator | Sonnenberg-Riethmacher, E Miehe, M Stolt, C C Goerich, D E Wegner, M Riethmacher, D |
| description | The HMG-domain transcription factor Sox10 is essential for the development of various neural crest derived lineages including glia and neurons of the peripheral nervous system (PNS). Within the PNS the most striking defect is the complete absence of glial differentiation whereas neurogenesis seemed initially normal. A degeneration of motoneurons and sensory neurons occurred later in development. The mechanism that leads to the dramatic effects on the neural crest derived cell lineages in the dorsal root ganglia (DRG), however, has not been examined up to now. Here, we provide a detailed analysis of proliferation and apoptosis in the DRG during the time of their generation and lineage segregation (between E 9.5 and E 11.5). We show that both increased apoptosis as well as decreased proliferation of neural crest cells contribute to the observed hypomorphism. |
| doi_str_mv | 10.1016/S0925-4773(01)00547-0 |
| format | Article |
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Within the PNS the most striking defect is the complete absence of glial differentiation whereas neurogenesis seemed initially normal. A degeneration of motoneurons and sensory neurons occurred later in development. The mechanism that leads to the dramatic effects on the neural crest derived cell lineages in the dorsal root ganglia (DRG), however, has not been examined up to now. Here, we provide a detailed analysis of proliferation and apoptosis in the DRG during the time of their generation and lineage segregation (between E 9.5 and E 11.5). 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We show that both increased apoptosis as well as decreased proliferation of neural crest cells contribute to the observed hypomorphism.</description><subject>Apoptosis</subject><subject>Cell Differentiation</subject><subject>Cell Division</subject><subject>Cell Lineage</subject><subject>DNA-Binding Proteins - genetics</subject><subject>DNA-Binding Proteins - physiology</subject><subject>Ganglia, Spinal - embryology</subject><subject>Ganglia, Spinal - metabolism</subject><subject>Genetic Markers</subject><subject>Heterozygote</subject><subject>High Mobility Group Proteins - chemistry</subject><subject>High Mobility Group Proteins - genetics</subject><subject>High Mobility Group Proteins - physiology</subject><subject>Homozygote</subject><subject>Immunohistochemistry</subject><subject>In Situ Hybridization</subject><subject>Lac Operon</subject><subject>Microscopy, Fluorescence</subject><subject>Neural Crest - cytology</subject><subject>Peripheral Nervous System - embryology</subject><subject>Protein Structure, Tertiary</subject><subject>SOXE Transcription Factors</subject><subject>Time Factors</subject><subject>Transcription Factors</subject><issn>0925-4773</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9jztPwzAUhT2AaCn8BJBHGALXsR07IyqlRSpiKMzV9SMhKLEjJyD49yi8pqPz0CcdQs4YXDFgxfUOylxmQil-AewSQAqVwQGZ_8czcjwMrwDAWMGOyIwxxVnO9ZzEW__u29h3PowUg6PO1z74hGMTA40VdTEN2NIU40hrDHXbIG0CHV88RTP4YP20muzmYZ252OHUJgyDTU3_TanQjjHRXfxgcEIOK2wHf_qrC_J8t3pabrLt4_p-ebPNeqaKMXNFWZUolbC5NHnBOSotlAFhOXqQzlSV1FZh7gvN0aAotbUatMRSGMUtX5DzH27_Zjrv9n1qOkyf-7_n_AuLzVsB</recordid><startdate>20011201</startdate><enddate>20011201</enddate><creator>Sonnenberg-Riethmacher, E</creator><creator>Miehe, M</creator><creator>Stolt, C C</creator><creator>Goerich, D E</creator><creator>Wegner, M</creator><creator>Riethmacher, D</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20011201</creationdate><title>Development and degeneration of dorsal root ganglia in the absence of the HMG-domain transcription factor Sox10</title><author>Sonnenberg-Riethmacher, E ; Miehe, M ; Stolt, C C ; Goerich, D E ; Wegner, M ; Riethmacher, D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p176t-d69f9a574c25b2633a7847b04c3ae05dbff58c7a2e683aba498cc8085a94b73c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Apoptosis</topic><topic>Cell Differentiation</topic><topic>Cell Division</topic><topic>Cell Lineage</topic><topic>DNA-Binding Proteins - genetics</topic><topic>DNA-Binding Proteins - physiology</topic><topic>Ganglia, Spinal - embryology</topic><topic>Ganglia, Spinal - metabolism</topic><topic>Genetic Markers</topic><topic>Heterozygote</topic><topic>High Mobility Group Proteins - chemistry</topic><topic>High Mobility Group Proteins - genetics</topic><topic>High Mobility Group Proteins - physiology</topic><topic>Homozygote</topic><topic>Immunohistochemistry</topic><topic>In Situ Hybridization</topic><topic>Lac Operon</topic><topic>Microscopy, Fluorescence</topic><topic>Neural Crest - cytology</topic><topic>Peripheral Nervous System - embryology</topic><topic>Protein Structure, Tertiary</topic><topic>SOXE Transcription Factors</topic><topic>Time Factors</topic><topic>Transcription Factors</topic><toplevel>online_resources</toplevel><creatorcontrib>Sonnenberg-Riethmacher, E</creatorcontrib><creatorcontrib>Miehe, M</creatorcontrib><creatorcontrib>Stolt, C C</creatorcontrib><creatorcontrib>Goerich, D E</creatorcontrib><creatorcontrib>Wegner, M</creatorcontrib><creatorcontrib>Riethmacher, D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Mechanisms of development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sonnenberg-Riethmacher, E</au><au>Miehe, M</au><au>Stolt, C C</au><au>Goerich, D E</au><au>Wegner, M</au><au>Riethmacher, D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development and degeneration of dorsal root ganglia in the absence of the HMG-domain transcription factor Sox10</atitle><jtitle>Mechanisms of development</jtitle><addtitle>Mech Dev</addtitle><date>2001-12-01</date><risdate>2001</risdate><volume>109</volume><issue>2</issue><spage>253</spage><pages>253-</pages><issn>0925-4773</issn><abstract>The HMG-domain transcription factor Sox10 is essential for the development of various neural crest derived lineages including glia and neurons of the peripheral nervous system (PNS). Within the PNS the most striking defect is the complete absence of glial differentiation whereas neurogenesis seemed initially normal. A degeneration of motoneurons and sensory neurons occurred later in development. The mechanism that leads to the dramatic effects on the neural crest derived cell lineages in the dorsal root ganglia (DRG), however, has not been examined up to now. Here, we provide a detailed analysis of proliferation and apoptosis in the DRG during the time of their generation and lineage segregation (between E 9.5 and E 11.5). We show that both increased apoptosis as well as decreased proliferation of neural crest cells contribute to the observed hypomorphism.</abstract><cop>Ireland</cop><pmid>11731238</pmid><doi>10.1016/S0925-4773(01)00547-0</doi></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Access via ScienceDirect (Elsevier) |
| subjects | Apoptosis Cell Differentiation Cell Division Cell Lineage DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology Ganglia, Spinal - embryology Ganglia, Spinal - metabolism Genetic Markers Heterozygote High Mobility Group Proteins - chemistry High Mobility Group Proteins - genetics High Mobility Group Proteins - physiology Homozygote Immunohistochemistry In Situ Hybridization Lac Operon Microscopy, Fluorescence Neural Crest - cytology Peripheral Nervous System - embryology Protein Structure, Tertiary SOXE Transcription Factors Time Factors Transcription Factors |
| title | Development and degeneration of dorsal root ganglia in the absence of the HMG-domain transcription factor Sox10 |
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