A new selective and potent inhibitor of human cytochrome P450 1B1 and its application to antimutagenesis
Human cytochrome P450 (P450) 1B1 is found mainly in extrahepatic tissues and is overexpressed in a variety of human tumors. Metabolic activation of 17beta-estradiol (E(2)) to 4-hydroxy E(2) by P450 1B1 has been postulated to be a factor in mammary carcinogenesis. The inhibition of recombinant human...
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Veröffentlicht in: | Cancer research (Chicago, Ill.) Ill.), 2001-11, Vol.61 (22), p.8164-8170 |
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