High frequency of deletions at the hypoxanthine-guanine phosphoribosyltransferase locus in an ataxia-telangiectasia lymphoblastoid cell line irradiated with gamma-rays

The molecular nature of gamma-ray-induced mutations at the hypoxanthine-guanine phosphoribosyltransferase (HPRT) locus in an ataxia-telangiectasia (A-T) lymphoblastoid cell line was investigated. Twelve of 15 gamma-ray-induced HPRT-deficient mutants showed deletions. Eight of them had lost the entir...

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Veröffentlicht in:	Japanese journal of cancer research (Gann) 2001-11, Vol.92 (11), p.1190
Hauptverfasser:	Tachibana, A, Tatsumi, K, Furuno-Fukushi, I, Sasaki, M S
Format:	Artikel
Sprache:	eng
Schlagworte:	Ataxia Telangiectasia - genetics Base Sequence Cell Line Chromosome Breakage - genetics Chromosome Deletion DNA Mutational Analysis Exons - genetics Gamma Rays - adverse effects Genetic Markers - genetics Humans Hypoxanthine Phosphoribosyltransferase - genetics Male Molecular Sequence Data Mutagenesis - radiation effects Physical Chromosome Mapping Polymerase Chain Reaction
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