A Randomized Clinical Trial of 4-Hydroxyphenylretinamide for High-Grade Squamous Intraepithelial Lesions of the Cervix

Purpose: Previous trials of topical trans -retinoic acid treatment of cervical intraepithelial neoplasia (CIN) grades 2 and 3 led to a statistically significant regression of CIN 2, but not CIN 3. We tested N -(4-hydroxyphenyl)retinamide (4-HPR), a promising oral retinoid that has been shown to indu...

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