Structural Genomics of Enzymes Involved in Sterol/Isoprenoid Biosynthesis

X-ray structures of two enzymes in the sterol/isoprenoid biosynthesis pathway have been determined in a structural genomics pilot study. Mevalonate-5-diphosphate decarboxylase (MDD) is a single-domain α/β protein that catalyzes the last of three sequential ATP-dependent reactions which convert meval...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2001-11, Vol.98 (23), p.12896-12901
Hauptverfasser:	Bonanno, Jeffrey B., Edo, Carme, Eswar, Narayanan, Pieper, Ursula, Romanowski, Michael J., Ilyin, Valentin, Gerchman, Sue Ellen, Kycia, Helen, Studier, F. William, Sali, Andrej, Burley, Stephen K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Biochemistry Biological Sciences BIOSYNTHESIS Crystallization Crystallography, X-Ray Diphosphates ENZYMES Enzymes - chemistry Enzymes - genetics Enzymes - metabolism Evolution Genome Genomes Genomics Humans ISOPRENE isoprenoids Models, Molecular Molecular Sequence Data Molecules NATIONAL SYNCHROTRON LIGHT SOURCE NSLS PARTICLE ACCELERATORS Protein Conformation Proteins Sequence Homology, Amino Acid Spatial models sterol STEROLS Z score
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