Altered Transcription in Yeast Expressing Expanded Polyglutamine

Expanded polyglutamine tracts are responsible for at least eight fatal neurodegenerative diseases. In mouse models, proteins with expanded polyglutamine cause transcriptional dysregulation before onset of symptoms, suggesting that this dysregulation may be an early event in polyglutamine pathogenesi...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2001-11, Vol.98 (23), p.13201-13206
Hauptverfasser:	Hughes, Robert E., Lo, Russell S., Davis, Colleen, Strand, Andrew D., Neal, Cassandra L., Olson, James M., Fields, Stanley
Format:	Artikel
Sprache:	eng
Schlagworte:	Ada protein Amino Acid Sequence Biological Sciences Cell Nucleus - metabolism Cellular metabolism CREB-binding protein Deoxyribonucleic acid DNA Fungal Proteins - genetics Gcn5 acetyltransferase Gene Deletion Gene Expression Profiling Genes Genetic diseases Heat shock response Histones Huntington disease Nervous system diseases Neurological disorders Peptides - genetics Peptides - metabolism Phosphates polyglutamine Promoter Regions, Genetic Proteins Proton-Phosphate Symporters - genetics Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae Proteins - genetics Shock heating Spt protein SPT3 gene Transcription Factors - genetics Transcription, Genetic Yeast Yeasts
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