Vasopeptidase inhibition restores renovascular endothelial dysfunction in salt-induced hypertension

Renovascular hemodynamics plays a pivotal role in the regulation of BP. The effect of the vasopeptidase inhibitor omapatrilat (O) and the ACE-inhibitor captopril (C) on endothelial function in the renal circulation in salt-induced hypertension were investigated. Dahl salt-sensitive rats (n = 6 per g...

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Veröffentlicht in:	Journal of the American Society of Nephrology 2001-11, Vol.12 (11), p.2280-2287
Hauptverfasser:	QUASCHNING, Thomas, D'USCIO, Livius V, SHAW, Sidney, GRÖNE, Hermann-Josef, RUSCHITZKA, Frank, LÜSCHER, Thomas F
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin-Converting Enzyme Inhibitors - pharmacology Animals Antihypertensive Agents - pharmacology Biological and medical sciences Blood Vessels - pathology Captopril - pharmacology Cardiomegaly - etiology Cardiomegaly - pathology Endothelium, Vascular - physiopathology Hypertension - chemically induced Hypertension - complications Hypertension - pathology Hypertension - physiopathology Hypertrophy Investigative techniques of renal and urinary tract function Investigative techniques, diagnostic techniques (general aspects) Kidney Glomerulus - pathology Male Medical sciences Myocardium - pathology Neprilysin - antagonists & inhibitors Protease Inhibitors - pharmacology Pyridines - pharmacology Rats Rats, Inbred Dahl Renal Circulation - drug effects Sodium Chloride Thiazepines - pharmacology Vasoconstriction Vasodilation
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