Induction of Nitric Oxide Synthase Activity in Nucleus Ambiguus Motoneurons after Injury to the Rat Recurrent Laryngeal Nerve
Recent studies have implicated nitric oxide (NO) in neuronal degeneration and plasticity in the motor nervous system. In the present study, we investigated the induction of nitric oxide synthase (NOS) in the motoneurons in the nucleus ambiguus (NA) after injury to the rat recurrent laryngeal nerve (...
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| Veröffentlicht in: | Acta oto-laryngologica 2000-01, Vol.120 (2), p.327-329 |
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| creator | Hitoshi Bamba, Toshiyuki Uno, Shinobu Koike, Kazuhiro Shogaki, Yasuo Hisa |
| description | Recent studies have implicated nitric oxide (NO) in neuronal degeneration and plasticity in the motor nervous system. In the present study, we investigated the induction of nitric oxide synthase (NOS) in the motoneurons in the nucleus ambiguus (NA) after injury to the rat recurrent laryngeal nerve (RLN) using nicotinamide-adenine-dinucleotide-phosphate-diaphorase (NADPH-d) histochemistry. NADPH-d reactivity was clearly induced in motoneurons in the ipsilateral NA after transection or avulsion of the RLN, compared with control animals. This finding suggests that NO may play an important role in the pathogenesis of RLN paralysis. Another interesting finding in the present study was the induction of NADPH-d reactivity in nerve terminals of the NA after RLN injury. This finding suggests that RLN injury has some effect on nitrergic input to the NA and a direct effect on the motoneurons. |
| doi_str_mv | 10.1080/000164800750001198 |
| format | Article |
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In the present study, we investigated the induction of nitric oxide synthase (NOS) in the motoneurons in the nucleus ambiguus (NA) after injury to the rat recurrent laryngeal nerve (RLN) using nicotinamide-adenine-dinucleotide-phosphate-diaphorase (NADPH-d) histochemistry. NADPH-d reactivity was clearly induced in motoneurons in the ipsilateral NA after transection or avulsion of the RLN, compared with control animals. This finding suggests that NO may play an important role in the pathogenesis of RLN paralysis. Another interesting finding in the present study was the induction of NADPH-d reactivity in nerve terminals of the NA after RLN injury. 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In the present study, we investigated the induction of nitric oxide synthase (NOS) in the motoneurons in the nucleus ambiguus (NA) after injury to the rat recurrent laryngeal nerve (RLN) using nicotinamide-adenine-dinucleotide-phosphate-diaphorase (NADPH-d) histochemistry. NADPH-d reactivity was clearly induced in motoneurons in the ipsilateral NA after transection or avulsion of the RLN, compared with control animals. This finding suggests that NO may play an important role in the pathogenesis of RLN paralysis. Another interesting finding in the present study was the induction of NADPH-d reactivity in nerve terminals of the NA after RLN injury. This finding suggests that RLN injury has some effect on nitrergic input to the NA and a direct effect on the motoneurons.</description><subject>Animals</subject><subject>Brain Stem - enzymology</subject><subject>Brain Stem - pathology</subject><subject>Enzyme Induction - physiology</subject><subject>Male</subject><subject>Motor Neurons - enzymology</subject><subject>Motor Neurons - pathology</subject><subject>NADPH Dehydrogenase - metabolism</subject><subject>Nerve Degeneration - enzymology</subject><subject>Nerve Degeneration - pathology</subject><subject>Nerve Endings - enzymology</subject><subject>Nerve Endings - pathology</subject><subject>Neuronal Plasticity - physiology</subject><subject>Nitric Oxide Synthase - metabolism</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Recurrent Laryngeal Nerve - pathology</subject><subject>Recurrent Laryngeal Nerve Injuries</subject><issn>0001-6489</issn><issn>1651-2251</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1vEzEQhi0EoqHwBzggn7gtjL3r_ZDgEFVtiRRSqcB55XjHjaNdu_ijsAf-O44SCSGkcvLY87zjmXkJec3gHYMW3gMAq6sWoBGHkHXtE7JgtWAF54I9JYvDa5GJ7oy8CGF_uHateE7OGKuhzMIF-bWyQ1LROEudphsTvVH05qcZkH6ZbdzJgHSZ8w8mztRYuklqxBToctqau5SDzy46i8k7G6jUET1d2X3yM42Oxh3SWxnpLarkPdpI19LP9g7lSDfoH_AleablGPDV6Twn364uv158KtY316uL5bpQAspYiGHYKjWUHEFDo7VsOGuBb-s8R8lq1LxpQWNVt6XshBYaBEInsG5413S6K8_J22Pde---Jwyxn0xQOI7Sokuhb3gNbVlV_wU5dFXFeJNBfgSVdyF41P29N1OermfQH9zp_3Uni96cqqfthMMfycmODHw8AsZq5yf5w_lx6KOcR-e1l1aZ0JePfvDhL_0ubzrulPTY713yNu_4sf5-AwWmsHM</recordid><startdate>20000101</startdate><enddate>20000101</enddate><creator>Hitoshi Bamba, Toshiyuki Uno, Shinobu Koike, Kazuhiro Shogaki, Yasuo Hisa</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>20000101</creationdate><title>Induction of Nitric Oxide Synthase Activity in Nucleus Ambiguus Motoneurons after Injury to the Rat Recurrent Laryngeal Nerve</title><author>Hitoshi Bamba, Toshiyuki Uno, Shinobu Koike, Kazuhiro Shogaki, Yasuo Hisa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-5ddbccd32e0f07ffa721802b6116316ef2780fe4683a95f5f05e095e672979f93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animals</topic><topic>Brain Stem - enzymology</topic><topic>Brain Stem - pathology</topic><topic>Enzyme Induction - physiology</topic><topic>Male</topic><topic>Motor Neurons - enzymology</topic><topic>Motor Neurons - pathology</topic><topic>NADPH Dehydrogenase - metabolism</topic><topic>Nerve Degeneration - enzymology</topic><topic>Nerve Degeneration - pathology</topic><topic>Nerve Endings - enzymology</topic><topic>Nerve Endings - pathology</topic><topic>Neuronal Plasticity - physiology</topic><topic>Nitric Oxide Synthase - metabolism</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Recurrent Laryngeal Nerve - pathology</topic><topic>Recurrent Laryngeal Nerve Injuries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hitoshi Bamba, Toshiyuki Uno, Shinobu Koike, Kazuhiro Shogaki, Yasuo Hisa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>Acta oto-laryngologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hitoshi Bamba, Toshiyuki Uno, Shinobu Koike, Kazuhiro Shogaki, Yasuo Hisa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Induction of Nitric Oxide Synthase Activity in Nucleus Ambiguus Motoneurons after Injury to the Rat Recurrent Laryngeal Nerve</atitle><jtitle>Acta oto-laryngologica</jtitle><addtitle>Acta Otolaryngol</addtitle><date>2000-01-01</date><risdate>2000</risdate><volume>120</volume><issue>2</issue><spage>327</spage><epage>329</epage><pages>327-329</pages><issn>0001-6489</issn><eissn>1651-2251</eissn><abstract>Recent studies have implicated nitric oxide (NO) in neuronal degeneration and plasticity in the motor nervous system. 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| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Access via Taylor & Francis |
| subjects | Animals Brain Stem - enzymology Brain Stem - pathology Enzyme Induction - physiology Male Motor Neurons - enzymology Motor Neurons - pathology NADPH Dehydrogenase - metabolism Nerve Degeneration - enzymology Nerve Degeneration - pathology Nerve Endings - enzymology Nerve Endings - pathology Neuronal Plasticity - physiology Nitric Oxide Synthase - metabolism Rats Rats, Sprague-Dawley Recurrent Laryngeal Nerve - pathology Recurrent Laryngeal Nerve Injuries |
| title | Induction of Nitric Oxide Synthase Activity in Nucleus Ambiguus Motoneurons after Injury to the Rat Recurrent Laryngeal Nerve |
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