Expression of Trp3 determines sensitivity of capacitative Ca2+ entry to nitric oxide and mitochondrial Ca2+ handling: evidence for a role of Trp3 as a subunit of capacitative Ca2+ entry channels

The role of Trp3 in cellular regulation of Ca(2+) entry by NO was studied in human embryonic kidney (HEK) 293 cells. In vector-transfected HEK293 cells (controls), thapsigargin (TG)-induced (capacitative Ca(2+) entry (CCE)-mediated) intracellular Ca(2+) signals and Mn(2+) entry were markedly suppres...

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Veröffentlicht in:The Journal of biological chemistry 2001-12, Vol.276 (51), p.48149
Hauptverfasser: Thyagarajan, B, Poteser, M, Romanin, C, Kahr, H, Zhu, M X, Groschner, K
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Sprache:eng
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