Cisplatin-induced apoptosis by translocation of endogenous Bax in mouse collecting duct cells

cis-Platinum(II) ( cis-diammine dichloroplatinum; cisplatin) is a potent antitumor compound that is widely used for the treatment of many malignancies. An important side-effect of cisplatin is nephrotoxicity, which results from injury to renal tubular epithelial cells and can be manifested as either...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemical pharmacology 2001-10, Vol.62 (8), p.1013-1023
Hauptverfasser:	Hwa Lee, Ryang, Mi Song, Jin, Young Park, Mi, Kyung Kang, Soo, Keun Kim, Yong, Sup Jung, Jin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Antioxidants - pharmacology Apoptosis Bax translocation Bcl-2 bcl-2-Associated X Protein Biological and medical sciences Biological Transport Cell Survival - drug effects Cells, Cultured Cisplatin Cisplatin - pharmacology Collecting duct Cytochrome c Group - metabolism Cytosol - metabolism Drug toxicity and drugs side effects treatment JNK Mitogen-Activated Protein Kinases Kidney Tubules, Collecting - cytology Kidney Tubules, Collecting - drug effects Kidney Tubules, Collecting - metabolism Medical sciences Mice Mitochondria - metabolism Mitogen-Activated Protein Kinases - physiology Pharmacology. Drug treatments Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-bcl-2 - physiology Toxicity: urogenital system
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!