Virus-directed, enzyme prodrug therapy with nitroimidazole reductase: A Phase I and pharmacokinetic study of its prodrug, CB1954

CB1954 [5-(aziridin-1-yl)-2,4-dinitrobenzamide] is converted by the bacterial enzyme nitroimidazole reductase (NTR) into a potent cytotoxic bifunctional alkylating agent, which can be delivered to tumors in adenoviral vectors as virus-directed, enzyme prodrug therapy. This report summarizes a Phase...

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Veröffentlicht in:	Clinical cancer research 2001-09, Vol.7 (9), p.2662-2668
Hauptverfasser:	CHUNG-FAYE, Guy, PALMER, Daniel, HARRIS, Peter A, FERRY, David, KERR, David J, ANDERSON, David, CLARK, Joanna, DOWNES, Mandy, BADDELEY, Joanna, HUSSAIN, Syed, MURRAY, Philip I, SEARLE, Peter, SEYMOUR, Leonard
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdominal Pain - chemically induced Adenoviridae - genetics Adult Aged Anorexia - chemically induced Antineoplastic agents Antineoplastic Agents - adverse effects Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - therapeutic use Aziridines - adverse effects Aziridines - pharmacokinetics Aziridines - therapeutic use Biological and medical sciences Chemotherapy Diarrhea - chemically induced Dose-Response Relationship, Drug Fatigue - chemically induced Female Gastrointestinal Neoplasms - genetics Gastrointestinal Neoplasms - metabolism Gastrointestinal Neoplasms - therapy Genetic Vectors - administration & dosage Humans Injections, Intraperitoneal Injections, Intravenous Male Medical sciences Middle Aged Nausea - chemically induced Nitroreductases - genetics Pharmacology. Drug treatments Prodrugs - adverse effects Prodrugs - pharmacokinetics Prodrugs - therapeutic use Treatment Outcome Vomiting - chemically induced
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