AKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho-mediated stress fiber formation

Guanine nucleotide exchange factors of the Dbl family relay signals from membrane receptors to Rho family GTPases. We now demonstrate that a longer transcript of the Lbc gene encodes a chimeric molecule, which we have called AKAP-Lbc, that functions as an A-kinase-anchoring protein (AKAP) and a Rho-...

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Veröffentlicht in:	The Journal of biological chemistry 2001-11, Vol.276 (47), p.44247
Hauptverfasser:	Diviani, D, Soderling, J, Scott, J D
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals Cell Line Cloning, Molecular Cyclic AMP-Dependent Protein Kinases - metabolism DNA, Complementary GTP-Binding Proteins - genetics GTP-Binding Proteins - metabolism Humans Mice Molecular Sequence Data Mutagenesis Protein Binding Recombinant Fusion Proteins - metabolism
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