Mechanisms associated with tumor vascular shut-down induced by combretastatin A-4 phosphate : Intravital microscopy and measurement of vascular permeability

The tumor vascular effects of the tubulin destabilizing agent disodium combretastatinA-4 3-O-phosphate (CA-4-P) were investigated in the rat P22 tumor growing in a dorsal skin flap window chamber implanted into BD9 rats. CA-4-P is in clinical trial as a tumor vascular targeting agent. In animal tumo...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2001-09, Vol.61 (17), p.6413-6422
Hauptverfasser:	TOZER, Gillian M, PRISE, Vivien E, WILSON, John, CEMAZAR, Maja, SIQING SHAN, DEWHIRST, Mark W, BARBER, Paul R, VOJNOVIC, Borivoj, CHAPLIN, David J
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Inhibitors - pharmacology Animals Antineoplastic agents Antineoplastic Agents, Phytogenic - pharmacology Biological and medical sciences Capillary Permeability - drug effects Carcinosarcoma - blood supply Carcinosarcoma - drug therapy Carcinosarcoma - metabolism Chemotherapy Drug Synergism Enzyme Inhibitors - pharmacology Male Medical sciences Microscopy, Fluorescence - methods Neoplasms, Experimental - blood supply Neoplasms, Experimental - drug therapy Neoplasms, Experimental - metabolism Neovascularization, Pathologic - drug therapy Neovascularization, Pathologic - physiopathology Nitric Oxide - biosynthesis Nitric Oxide - physiology Nitric Oxide Synthase - antagonists & inhibitors Nitroarginine - pharmacology Pharmacology. Drug treatments Rats Stilbenes - pharmacology
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