Activation of β-Major Globin Gene Transcription is Associated with Recruitment of NF-E2 to the β-Globin LCR and Gene Promoter

The mouse β-globin gene locus control region (LCR), located upstream of the β-globin gene cluster, is essential for the activated transcription of genes in the cluster. The LCR contains multiple binding sites for transactivators, including Maf-recognition elements (MAREs). However, little is known a...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2001-08, Vol.98 (18), p.10226-10231
Hauptverfasser:	Sawado, Tomoyuki, Igarashi, Kazuhiko, Groudine, Mark
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Animals Antibodies Antiserum b-globin Bacterial Proteins - genetics Biological Sciences Cell Line Chromatin DNA-Binding Proteins - metabolism Erythroid-Specific DNA-Binding Factors erythroleukemia cells Gene Expression Regulation Gene induction Genes Genetic loci Globins - genetics Histones Histones - metabolism Leukemia, Erythroblastic, Acute - genetics Leukemia, Erythroblastic, Acute - metabolism Locus Control Region MafK protein MafK Transcription Factor Mice Models, Biological Multigene Family NF-E2 protein NF-E2 Transcription Factor NF-E2 Transcription Factor, p45 Subunit Polymerase chain reaction Promoter Regions, Genetic Transcription Factors - metabolism Transcription, Genetic Tumor Cells, Cultured
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