Homology model of dihydropyridine receptor: implications for L-type Ca(2+) channel modulation by agonists and antagonists

L-type calcium channels (LCCs) are transmembrane (TM) proteins that respond to membrane depolarization by selectively permeating Ca(2+) ions. Dihydropyridine (DHP) agonists and antagonist modulate Ca(2+) permeation by stabilizing, respectively, the open and closed states of the channel. The mechanis...

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Veröffentlicht in:	Archives of biochemistry and biophysics 2001-09, Vol.393 (1), p.22
Hauptverfasser:	Zhorov, B S, Folkman, E V, Ananthanarayanan, V S
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Bacterial Proteins Binding Sites - genetics Biophysical Phenomena Biophysics Calcium Channels, L-Type - chemistry Calcium Channels, L-Type - drug effects Calcium Channels, L-Type - genetics Calcium Channels, L-Type - metabolism In Vitro Techniques Ion Channel Gating Ligands Models, Molecular Molecular Sequence Data Mutagenesis, Site-Directed Nifedipine - metabolism Potassium Channels - chemistry Potassium Channels - genetics Protein Conformation Rabbits Sequence Homology, Amino Acid
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