Glucotoxicity and lipotoxicity: factors in the pathogenesis and evolution of type 2 diabetes

Glucose toxicity refers to the structural and functional damage in the beta cells and target tissues of insulin, caused by chronic hyperglycemia. These alterations cause a lower hormonal secretion and action (insulin resistance). Lipid toxicity refers to the damage caused by persistently high free f...

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Veröffentlicht in:	Revista medíca de Chile 2001-06, Vol.129 (6), p.671
Hauptverfasser:	Durruty, P, García de los Ríos, M
Format:	Artikel
Sprache:	spa
Schlagworte:	Animals Diabetes Mellitus, Type 2 - etiology Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - prevention & control Fatty Acids, Nonesterified - metabolism Glucose - metabolism Glucose Intolerance - metabolism Humans Hyperglycemia - complications Hyperglycemia - metabolism Hypoglycemia - metabolism Insulin - metabolism Insulin Resistance - physiology Insulin Secretion Lipid Metabolism
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