Effects of bright light and melatonin on sleep propensity, temperature, and cardiac activity at night
Centre for Sleep Research, University of South Australia, Woodville, South Australia 5011, Australia Melatonin increases sleepiness, decreases core temperature, and increases peripheral temperature in humans. Melatonin may produce these effects by activating peripheral receptors or altering autonomi...
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| Veröffentlicht in: | Journal of applied physiology (1985) 2001-09, Vol.91 (3), p.1214-1222 |
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| container_title | Journal of applied physiology (1985) |
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| creator | Burgess, Helen J Sletten, Tracey Savic, Natasha Gilbert, Saul S Dawson, Drew |
| description | Centre for Sleep Research, University of South Australia,
Woodville, South Australia 5011, Australia
Melatonin increases
sleepiness, decreases core temperature, and increases peripheral
temperature in humans. Melatonin may produce these effects by
activating peripheral receptors or altering autonomic activity. The
latter hypothesis was investigated in 16 supine subjects. Three
conditions were created by using bright light and exogenous melatonin:
normal endogenous, suppressed, and pharmacological melatonin levels.
Data during wakefulness from 1.5 h before to 2.5 h after each
subject's estimated melatonin onset (wake time + 14 h) were
analyzed. Respiratory sinus arrhythmia (cardiac parasympathetic
activity) and preejection period (cardiac sympathetic activity) did not
vary among conditions. Pharmacological melatonin levels significantly
decreased systolic blood pressure [5.75 ± 1.65 (SE) mmHg] but
did not significantly change heart rate. Suppressed melatonin
significantly increased rectal temperature (0.27 ± 0.06°C),
decreased foot temperature (1.98 ± 0.70°C), and increased sleep
onset latency (5.53 ± 1.87 min). Thus melatonin does not
significantly alter cardiac autonomic activity and instead may bind to
peripheral receptors in the vasculature and heart. Furthermore,
increases in cardiac parasympathetic activity before normal nighttime
sleep cannot be attributed to the concomitant increase in endogenous melatonin.
heart rate variability; respiratory; sympathetic |
| doi_str_mv | 10.1152/jappl.2001.91.3.1214 |
| format | Article |
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Woodville, South Australia 5011, Australia
Melatonin increases
sleepiness, decreases core temperature, and increases peripheral
temperature in humans. Melatonin may produce these effects by
activating peripheral receptors or altering autonomic activity. The
latter hypothesis was investigated in 16 supine subjects. Three
conditions were created by using bright light and exogenous melatonin:
normal endogenous, suppressed, and pharmacological melatonin levels.
Data during wakefulness from 1.5 h before to 2.5 h after each
subject's estimated melatonin onset (wake time + 14 h) were
analyzed. Respiratory sinus arrhythmia (cardiac parasympathetic
activity) and preejection period (cardiac sympathetic activity) did not
vary among conditions. Pharmacological melatonin levels significantly
decreased systolic blood pressure [5.75 ± 1.65 (SE) mmHg] but
did not significantly change heart rate. Suppressed melatonin
significantly increased rectal temperature (0.27 ± 0.06°C),
decreased foot temperature (1.98 ± 0.70°C), and increased sleep
onset latency (5.53 ± 1.87 min). Thus melatonin does not
significantly alter cardiac autonomic activity and instead may bind to
peripheral receptors in the vasculature and heart. Furthermore,
increases in cardiac parasympathetic activity before normal nighttime
sleep cannot be attributed to the concomitant increase in endogenous melatonin.
heart rate variability; respiratory; sympathetic</description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/jappl.2001.91.3.1214</identifier><identifier>PMID: 11509518</identifier><identifier>CODEN: JAPHEV</identifier><language>eng</language><publisher>Bethesda, MD: Am Physiological Soc</publisher><subject>Adult ; Anticonvulsants - administration & dosage ; Anticonvulsants - analysis ; Arrhythmia, Sinus - physiopathology ; Biological and medical sciences ; Blood Pressure - drug effects ; Blood Pressure - physiology ; Body Temperature - drug effects ; Body Temperature - physiology ; Circadian Rhythm - drug effects ; Circadian Rhythm - physiology ; Effects ; Female ; Fundamental and applied biological sciences. Psychology ; Heart ; Heart Rate - drug effects ; Heart Rate - physiology ; Hormones ; Humans ; Light ; Lighting ; Male ; Melatonin - administration & dosage ; Melatonin - analysis ; Respiration ; Respiratory system ; Saliva - chemistry ; Sleep ; Sleep - drug effects ; Sleep - physiology ; Space life sciences ; Sympathetic Nervous System - physiology ; Temperature ; Thermoregulation. Hibernation. Estivation. Ecophysiology and environmental effects ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Journal of applied physiology (1985), 2001-09, Vol.91 (3), p.1214-1222</ispartof><rights>2002 INIST-CNRS</rights><rights>Copyright American Physiological Society Sep 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c504t-ecbf6aa948587506dc74721902386569de0ba4314733a073e73f7ea86f2830df3</citedby><cites>FETCH-LOGICAL-c504t-ecbf6aa948587506dc74721902386569de0ba4314733a073e73f7ea86f2830df3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3039,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14100673$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11509518$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Burgess, Helen J</creatorcontrib><creatorcontrib>Sletten, Tracey</creatorcontrib><creatorcontrib>Savic, Natasha</creatorcontrib><creatorcontrib>Gilbert, Saul S</creatorcontrib><creatorcontrib>Dawson, Drew</creatorcontrib><title>Effects of bright light and melatonin on sleep propensity, temperature, and cardiac activity at night</title><title>Journal of applied physiology (1985)</title><addtitle>J Appl Physiol (1985)</addtitle><description>Centre for Sleep Research, University of South Australia,
Woodville, South Australia 5011, Australia
Melatonin increases
sleepiness, decreases core temperature, and increases peripheral
temperature in humans. Melatonin may produce these effects by
activating peripheral receptors or altering autonomic activity. The
latter hypothesis was investigated in 16 supine subjects. Three
conditions were created by using bright light and exogenous melatonin:
normal endogenous, suppressed, and pharmacological melatonin levels.
Data during wakefulness from 1.5 h before to 2.5 h after each
subject's estimated melatonin onset (wake time + 14 h) were
analyzed. Respiratory sinus arrhythmia (cardiac parasympathetic
activity) and preejection period (cardiac sympathetic activity) did not
vary among conditions. Pharmacological melatonin levels significantly
decreased systolic blood pressure [5.75 ± 1.65 (SE) mmHg] but
did not significantly change heart rate. Suppressed melatonin
significantly increased rectal temperature (0.27 ± 0.06°C),
decreased foot temperature (1.98 ± 0.70°C), and increased sleep
onset latency (5.53 ± 1.87 min). Thus melatonin does not
significantly alter cardiac autonomic activity and instead may bind to
peripheral receptors in the vasculature and heart. Furthermore,
increases in cardiac parasympathetic activity before normal nighttime
sleep cannot be attributed to the concomitant increase in endogenous melatonin.
heart rate variability; respiratory; sympathetic</description><subject>Adult</subject><subject>Anticonvulsants - administration & dosage</subject><subject>Anticonvulsants - analysis</subject><subject>Arrhythmia, Sinus - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Blood Pressure - physiology</subject><subject>Body Temperature - drug effects</subject><subject>Body Temperature - physiology</subject><subject>Circadian Rhythm - drug effects</subject><subject>Circadian Rhythm - physiology</subject><subject>Effects</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Heart</subject><subject>Heart Rate - drug effects</subject><subject>Heart Rate - physiology</subject><subject>Hormones</subject><subject>Humans</subject><subject>Light</subject><subject>Lighting</subject><subject>Male</subject><subject>Melatonin - administration & dosage</subject><subject>Melatonin - analysis</subject><subject>Respiration</subject><subject>Respiratory system</subject><subject>Saliva - chemistry</subject><subject>Sleep</subject><subject>Sleep - drug effects</subject><subject>Sleep - physiology</subject><subject>Space life sciences</subject><subject>Sympathetic Nervous System - physiology</subject><subject>Temperature</subject><subject>Thermoregulation. Hibernation. Estivation. Ecophysiology and environmental effects</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUtv1DAUhS1ERYeBf4CQhQRi0QS_EidLVLVQqRKbsrY8znXHI-eB7RTm3-PMjKio1I3vwt8593EQekdJSWnFvuz0NPmSEULLlpa8pIyKF2iVv1hBa0JfolUjK1LIqpHn6HWMu4wKUdFX6DwbkLaizQrBlbVgUsSjxZvg7rcJ-8Orhw734HUaBzfgccDRA0x4CuMEQ3Rpf4ET9BMEneYAFwfe6NA5bbA2yT1kBOuEh8XtDTqz2kd4e6pr9PP66u7ye3H749vN5dfbwlREpALMxtZat6KpltHrzkghGW0J401d1W0HZKMFp0JyronkILmVoJvasoaTzvI1-nT0zWP-miEm1btowHs9wDhHJWleW9Imgx-egLtxDkOeTTHGaCVJIzIkjpAJY4wBrJqC63XYK0rUkoE6ZKCWDFRLFVdLBln2_uQ9b3roHkWno2fg4wnQ0Whvgx6Mi4-coITUecU1-nzktvmGv10ANW330Y1-vN8vrf_rKZ5Hr2fv7-BPWjT_JGrK9_oLmWuxAg</recordid><startdate>20010901</startdate><enddate>20010901</enddate><creator>Burgess, Helen J</creator><creator>Sletten, Tracey</creator><creator>Savic, Natasha</creator><creator>Gilbert, Saul S</creator><creator>Dawson, Drew</creator><general>Am Physiological Soc</general><general>American Physiological Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20010901</creationdate><title>Effects of bright light and melatonin on sleep propensity, temperature, and cardiac activity at night</title><author>Burgess, Helen J ; Sletten, Tracey ; Savic, Natasha ; Gilbert, Saul S ; Dawson, Drew</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c504t-ecbf6aa948587506dc74721902386569de0ba4314733a073e73f7ea86f2830df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Anticonvulsants - administration & dosage</topic><topic>Anticonvulsants - analysis</topic><topic>Arrhythmia, Sinus - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Blood Pressure - physiology</topic><topic>Body Temperature - drug effects</topic><topic>Body Temperature - physiology</topic><topic>Circadian Rhythm - drug effects</topic><topic>Circadian Rhythm - physiology</topic><topic>Effects</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Heart</topic><topic>Heart Rate - drug effects</topic><topic>Heart Rate - physiology</topic><topic>Hormones</topic><topic>Humans</topic><topic>Light</topic><topic>Lighting</topic><topic>Male</topic><topic>Melatonin - administration & dosage</topic><topic>Melatonin - analysis</topic><topic>Respiration</topic><topic>Respiratory system</topic><topic>Saliva - chemistry</topic><topic>Sleep</topic><topic>Sleep - drug effects</topic><topic>Sleep - physiology</topic><topic>Space life sciences</topic><topic>Sympathetic Nervous System - physiology</topic><topic>Temperature</topic><topic>Thermoregulation. Hibernation. Estivation. Ecophysiology and environmental effects</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Burgess, Helen J</creatorcontrib><creatorcontrib>Sletten, Tracey</creatorcontrib><creatorcontrib>Savic, Natasha</creatorcontrib><creatorcontrib>Gilbert, Saul S</creatorcontrib><creatorcontrib>Dawson, Drew</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of applied physiology (1985)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Burgess, Helen J</au><au>Sletten, Tracey</au><au>Savic, Natasha</au><au>Gilbert, Saul S</au><au>Dawson, Drew</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of bright light and melatonin on sleep propensity, temperature, and cardiac activity at night</atitle><jtitle>Journal of applied physiology (1985)</jtitle><addtitle>J Appl Physiol (1985)</addtitle><date>2001-09-01</date><risdate>2001</risdate><volume>91</volume><issue>3</issue><spage>1214</spage><epage>1222</epage><pages>1214-1222</pages><issn>8750-7587</issn><eissn>1522-1601</eissn><coden>JAPHEV</coden><abstract>Centre for Sleep Research, University of South Australia,
Woodville, South Australia 5011, Australia
Melatonin increases
sleepiness, decreases core temperature, and increases peripheral
temperature in humans. Melatonin may produce these effects by
activating peripheral receptors or altering autonomic activity. The
latter hypothesis was investigated in 16 supine subjects. Three
conditions were created by using bright light and exogenous melatonin:
normal endogenous, suppressed, and pharmacological melatonin levels.
Data during wakefulness from 1.5 h before to 2.5 h after each
subject's estimated melatonin onset (wake time + 14 h) were
analyzed. Respiratory sinus arrhythmia (cardiac parasympathetic
activity) and preejection period (cardiac sympathetic activity) did not
vary among conditions. Pharmacological melatonin levels significantly
decreased systolic blood pressure [5.75 ± 1.65 (SE) mmHg] but
did not significantly change heart rate. Suppressed melatonin
significantly increased rectal temperature (0.27 ± 0.06°C),
decreased foot temperature (1.98 ± 0.70°C), and increased sleep
onset latency (5.53 ± 1.87 min). Thus melatonin does not
significantly alter cardiac autonomic activity and instead may bind to
peripheral receptors in the vasculature and heart. Furthermore,
increases in cardiac parasympathetic activity before normal nighttime
sleep cannot be attributed to the concomitant increase in endogenous melatonin.
heart rate variability; respiratory; sympathetic</abstract><cop>Bethesda, MD</cop><pub>Am Physiological Soc</pub><pmid>11509518</pmid><doi>10.1152/jappl.2001.91.3.1214</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 8750-7587 |
| ispartof | Journal of applied physiology (1985), 2001-09, Vol.91 (3), p.1214-1222 |
| issn | 8750-7587 1522-1601 |
| language | eng |
| recordid | cdi_pubmed_primary_11509518 |
| source | MEDLINE; American Physiological Society Paid; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Anticonvulsants - administration & dosage Anticonvulsants - analysis Arrhythmia, Sinus - physiopathology Biological and medical sciences Blood Pressure - drug effects Blood Pressure - physiology Body Temperature - drug effects Body Temperature - physiology Circadian Rhythm - drug effects Circadian Rhythm - physiology Effects Female Fundamental and applied biological sciences. Psychology Heart Heart Rate - drug effects Heart Rate - physiology Hormones Humans Light Lighting Male Melatonin - administration & dosage Melatonin - analysis Respiration Respiratory system Saliva - chemistry Sleep Sleep - drug effects Sleep - physiology Space life sciences Sympathetic Nervous System - physiology Temperature Thermoregulation. Hibernation. Estivation. Ecophysiology and environmental effects Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Effects of bright light and melatonin on sleep propensity, temperature, and cardiac activity at night |
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