Role of endogenous nitric oxide in liver-specific functions and survival of cultured rat hepatocytes

1. The role of endogenous nitric oxide in rat hepatocyte functionality and survival in cell culture was examined. Towards this aim, cytochrome P450 activities (CYP1A1/2, 2B1, 2A1, 2C11, 2D1, 2E1 and 3A1), liver-specific metabolic functions and cell survival were comparatively evaluated in hepatocyte...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Xenobiotica 2001-05, Vol.31 (5), p.249-264
Hauptverfasser:	Donato, M. T., Ponsoda, X., O'Connor, E., Castell, J. V., Gómez-Lechón, M. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	7-Alkoxycoumarin O-Dealkylase - metabolism Animals Biological and medical sciences Caspase 3 Caspases - metabolism Cell cultures. Hybridization. Fusion Cell Survival Cells, Cultured Cellular Senescence Cytochrome P-450 Enzyme System - metabolism Cytochrome P-450 Enzyme System - physiology DNA - metabolism Enzyme Inhibitors - pharmacology Flow Cytometry Fundamental and applied biological sciences. Psychology General aspects Glycogen - pharmacology Hepatocytes - drug effects Hepatocytes - metabolism Liver - metabolism Liver - physiology Male Molecular and cellular biology N-Omega-nitro-L-arginine methyl ester NG-Nitroarginine Methyl Ester - pharmacology Nitric Oxide - physiology nitro-L-arginine methyl ester Phenotype Rats Rats, Sprague-Dawley Time Factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!