Interleukin-18 Is Elevated in the Sera from Patients with Atopic Dermatitis and from Atopic Dermatitis Model Mice, NC/Nga
Background: Several lines of in vitro and in vivo studies have demonstrated that interleukin-18 (IL-18) shows both antiallergic and allergy-promoting activities. But its expression in allergic diseases remains unknown. Methods: Serum IL-18 levels from atopic dermatitis (AD) model mice, NC/Nga and co...
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| Veröffentlicht in: | International archives of allergy and immunology 2001-07, Vol.125 (3), p.236-240 |
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| creator | Tanaka, Toshio Tsutsui, Hiroko Yoshimoto, Tomohiro Kotani, Mayumi Matsumoto, Motonobu Fujita, Akihito Wang, Way Higa, Shinji Koshimoto, Tadamitsu Nakanishi, Kenji Suemura, Masaki |
| description | Background: Several lines of in vitro and in vivo studies have demonstrated that interleukin-18 (IL-18) shows both antiallergic and allergy-promoting activities. But its expression in allergic diseases remains unknown. Methods: Serum IL-18 levels from atopic dermatitis (AD) model mice, NC/Nga and control mice and from patients with AD and healthy volunteers were measured by ELISA. The relationship between IL-18 levels and serum IgE levels or clinical severity was also examined. Results: Serum IL-18 levels from NC/Nga mice were significantly increased compared to those from control mice. The elevation of IL-18 in the sera was observed prior to the onset and during the development of dermatitis in NC/Nga mice. In addition, IL-18 levels in the sera from patients with AD were significantly (p < 0.05) elevated compared to those from healthy volunteers. However, serum IL-18 levels tended to correlate negatively with serum IgE levels in patients with AD and NC/Nga mice. Conclusion: IL-18 is overexpressed in AD. |
| doi_str_mv | 10.1159/000053821 |
| format | Article |
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But its expression in allergic diseases remains unknown. Methods: Serum IL-18 levels from atopic dermatitis (AD) model mice, NC/Nga and control mice and from patients with AD and healthy volunteers were measured by ELISA. The relationship between IL-18 levels and serum IgE levels or clinical severity was also examined. Results: Serum IL-18 levels from NC/Nga mice were significantly increased compared to those from control mice. The elevation of IL-18 in the sera was observed prior to the onset and during the development of dermatitis in NC/Nga mice. In addition, IL-18 levels in the sera from patients with AD were significantly (p < 0.05) elevated compared to those from healthy volunteers. However, serum IL-18 levels tended to correlate negatively with serum IgE levels in patients with AD and NC/Nga mice. Conclusion: IL-18 is overexpressed in AD.</description><identifier>ISSN: 1018-2438</identifier><identifier>EISSN: 1423-0097</identifier><identifier>DOI: 10.1159/000053821</identifier><identifier>PMID: 11490156</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Adolescent ; Adult ; Allergic diseases ; Animals ; Biological and medical sciences ; Dermatitis, Atopic - blood ; Disease Models, Animal ; Humans ; Immunoglobulin E - blood ; Immunopathology ; Interleukin-18 - blood ; Medical sciences ; Mice ; Original Paper ; Skin allergic diseases. Stinging insect allergies ; Specific Pathogen-Free Organisms</subject><ispartof>International archives of allergy and immunology, 2001-07, Vol.125 (3), p.236-240</ispartof><rights>2001 S. Karger AG, Basel</rights><rights>2002 INIST-CNRS</rights><rights>Copyright 2001 S. Karger AG, Basel.</rights><rights>Copyright (c) 2001 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-bdd5f4d0fe07499d3fd2bf7f33480ea537739627b344b38cee6febf28d2d57893</citedby><cites>FETCH-LOGICAL-c450t-bdd5f4d0fe07499d3fd2bf7f33480ea537739627b344b38cee6febf28d2d57893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2423,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14086551$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11490156$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tanaka, Toshio</creatorcontrib><creatorcontrib>Tsutsui, Hiroko</creatorcontrib><creatorcontrib>Yoshimoto, Tomohiro</creatorcontrib><creatorcontrib>Kotani, Mayumi</creatorcontrib><creatorcontrib>Matsumoto, Motonobu</creatorcontrib><creatorcontrib>Fujita, Akihito</creatorcontrib><creatorcontrib>Wang, Way</creatorcontrib><creatorcontrib>Higa, Shinji</creatorcontrib><creatorcontrib>Koshimoto, Tadamitsu</creatorcontrib><creatorcontrib>Nakanishi, Kenji</creatorcontrib><creatorcontrib>Suemura, Masaki</creatorcontrib><title>Interleukin-18 Is Elevated in the Sera from Patients with Atopic Dermatitis and from Atopic Dermatitis Model Mice, NC/Nga</title><title>International archives of allergy and immunology</title><addtitle>Int Arch Allergy Immunol</addtitle><description>Background: Several lines of in vitro and in vivo studies have demonstrated that interleukin-18 (IL-18) shows both antiallergic and allergy-promoting activities. But its expression in allergic diseases remains unknown. Methods: Serum IL-18 levels from atopic dermatitis (AD) model mice, NC/Nga and control mice and from patients with AD and healthy volunteers were measured by ELISA. The relationship between IL-18 levels and serum IgE levels or clinical severity was also examined. Results: Serum IL-18 levels from NC/Nga mice were significantly increased compared to those from control mice. The elevation of IL-18 in the sera was observed prior to the onset and during the development of dermatitis in NC/Nga mice. In addition, IL-18 levels in the sera from patients with AD were significantly (p < 0.05) elevated compared to those from healthy volunteers. However, serum IL-18 levels tended to correlate negatively with serum IgE levels in patients with AD and NC/Nga mice. Conclusion: IL-18 is overexpressed in AD.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Allergic diseases</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Dermatitis, Atopic - blood</subject><subject>Disease Models, Animal</subject><subject>Humans</subject><subject>Immunoglobulin E - blood</subject><subject>Immunopathology</subject><subject>Interleukin-18 - blood</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Original Paper</subject><subject>Skin allergic diseases. Stinging insect allergies</subject><subject>Specific Pathogen-Free Organisms</subject><issn>1018-2438</issn><issn>1423-0097</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqF0dtrFDEUB-Agiq3VB58FCQUVwbG5TpLHZa260FZBfR4yk5M27VzWJKP0vzfrri2oaF5yOR-_QzgIPabkNaXSHJGyJNeM3kH7VDBeEWLU3XImVFdMcL2HHqR0SUjBur6P9igVplzqfXS9GjPEHuarMFZU41XCxz18sxkcDiPOF4A_QbTYx2nAH20OMOaEv4d8gRd5WocOv4E4lPccEraj28I_S6eTgx6fhg5e4bPl0dm5fYjuedsneLTbD9CXt8efl--rkw_vVsvFSdUJSXLVOie9cMQDUcIYx71jrVeec6EJWMmV4qZmquVCtFx3ALWH1jPtmJNKG36AXmxz13H6OkPKzRBSB31vR5jm1ChRM06UoUU-_7ekpOaU1f-FVFPNJNMFHv4GL6c5juW7DWNUC2HEJu3lFnVxSimCb9YxDDZeN5Q0m_k2N_Mt9ukucG4HcLdyN9ACnu2ATZ3tfbRjF9KtE0TXUm6CnmzdlY3nEG_ArzaHf62uFoufoFk7z38A4oi-ww</recordid><startdate>20010701</startdate><enddate>20010701</enddate><creator>Tanaka, Toshio</creator><creator>Tsutsui, Hiroko</creator><creator>Yoshimoto, Tomohiro</creator><creator>Kotani, Mayumi</creator><creator>Matsumoto, Motonobu</creator><creator>Fujita, Akihito</creator><creator>Wang, Way</creator><creator>Higa, Shinji</creator><creator>Koshimoto, Tadamitsu</creator><creator>Nakanishi, Kenji</creator><creator>Suemura, Masaki</creator><general>Karger</general><general>S. 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But its expression in allergic diseases remains unknown. Methods: Serum IL-18 levels from atopic dermatitis (AD) model mice, NC/Nga and control mice and from patients with AD and healthy volunteers were measured by ELISA. The relationship between IL-18 levels and serum IgE levels or clinical severity was also examined. Results: Serum IL-18 levels from NC/Nga mice were significantly increased compared to those from control mice. The elevation of IL-18 in the sera was observed prior to the onset and during the development of dermatitis in NC/Nga mice. In addition, IL-18 levels in the sera from patients with AD were significantly (p < 0.05) elevated compared to those from healthy volunteers. However, serum IL-18 levels tended to correlate negatively with serum IgE levels in patients with AD and NC/Nga mice. Conclusion: IL-18 is overexpressed in AD.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>11490156</pmid><doi>10.1159/000053821</doi><tpages>5</tpages></addata></record> |
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| ispartof | International archives of allergy and immunology, 2001-07, Vol.125 (3), p.236-240 |
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| language | eng |
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| source | Karger Journals; MEDLINE; Alma/SFX Local Collection |
| subjects | Adolescent Adult Allergic diseases Animals Biological and medical sciences Dermatitis, Atopic - blood Disease Models, Animal Humans Immunoglobulin E - blood Immunopathology Interleukin-18 - blood Medical sciences Mice Original Paper Skin allergic diseases. Stinging insect allergies Specific Pathogen-Free Organisms |
| title | Interleukin-18 Is Elevated in the Sera from Patients with Atopic Dermatitis and from Atopic Dermatitis Model Mice, NC/Nga |
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