Effect of bile acids on the proliferative activity and apoptosis of rat hepatocytes

Bile acids are known to have damaging as well as protective effects on liver cells. A likely candidate for bile acid-mediated hepatocellular injury during cholestasis is glycochenodeoxycholic acid (GCDCA), a hydrophobic bile acid with a direct cytotoxic effect on hepatocytes. In contrast, ursodeoxyc...

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Veröffentlicht in:	Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2001-06, Vol.53 (2-3), p.227-233
Hauptverfasser:	DANCHENKO, Elena, PETERMANN, Henning, CHIRKIN, Alexander, DARGEL, Rolf
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Biological and medical sciences Cell Division - drug effects Cells, Cultured DNA - analysis DNA - biosynthesis DNA Fragmentation Dose-Response Relationship, Drug Drug Antagonism Gastroenterology. Liver. Pancreas. Abdomen Glycochenodeoxycholic Acid - toxicity Hepatocytes - drug effects Hepatocytes - metabolism Hepatocytes - pathology L-Lactate Dehydrogenase - metabolism Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Other diseases. Semiology Protein Biosynthesis Rats Rats, Wistar Taurochenodeoxycholic Acid - pharmacology Ursodeoxycholic Acid - toxicity
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