Rhabdomyolysis and acute renal failure secondary to statins

Statins are competitive inhibitors of hydroxy-methyl-glutaryl coenzyme A (HMG-CoA) reductase and are the most commonly used drugs to treat hyperlipidaemia. Muscle toxicity is an adverse effect reported with a low incidence and rarely associated with acute renal failure due to rhabdomyolysis. We desc...

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Veröffentlicht in:	Nefrología 2001-05, Vol.21 (3), p.309
Hauptverfasser:	Borrego, F J, Liébana, A, Borrego, J, Pérez del Barrio, P, Gil, J M, García Cortés, M J, Sánchez Perales, C, Serrano, P, Pérez Bañasco, V
Format:	Artikel
Sprache:	spa
Schlagworte:	Acute Kidney Injury - etiology Aged Back Pain - drug therapy Bezafibrate - pharmacology Bezafibrate - therapeutic use Cytochrome P-450 CYP3A Cytochrome P-450 Enzyme System - metabolism Diuresis Drug Synergism Fatal Outcome Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacokinetics Hypercholesterolemia - complications Hypercholesterolemia - drug therapy Inactivation, Metabolic Indomethacin - adverse effects Indomethacin - pharmacokinetics Kidney Failure, Chronic - complications Kidney Failure, Chronic - metabolism Male Middle Aged Mixed Function Oxygenases - metabolism Multiple Organ Failure - etiology Pravastatin - adverse effects Pravastatin - pharmacokinetics Renal Dialysis Rhabdomyolysis - chemically induced Rhabdomyolysis - complications Risk Factors Sepsis - complications Simvastatin - adverse effects
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