Hysteresivity of the lung and tissue strip in the normal rat: effects of heterogeneities
1 Department of Biomedical Engineering, Boston University, Boston 02215; and 2 Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115 We measured lung impedance in rats in closed chest (CC), open chest (OC), and isolated lungs (IL) at four...
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| Veröffentlicht in: | Journal of applied physiology (1985) 2001-08, Vol.91 (2), p.737-747 |
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| container_title | Journal of applied physiology (1985) |
| container_volume | 91 |
| creator | Sakai, Hiroaki Ingenito, Edward P Mora, Rene Abbay, Senay Cavalcante, Francisco S. A Lutchen, Kenneth R Suki, Bela |
| description | 1 Department of Biomedical Engineering, Boston University,
Boston 02215; and 2 Division of Pulmonary and Critical Care
Medicine, Brigham and Women's Hospital, Boston, Massachusetts
02115
We measured lung impedance in rats in closed
chest (CC), open chest (OC), and isolated lungs (IL) at four
transpulmonary pressures with a optimal ventilator waveform.
Data were analyzed with an homogeneous linear or an inhomogeneous
linear model. Both models include tissue damping and elastance and
airway inertance. The homogeneous linear model includes airway
resistance (Raw), whereas the inhomogeneous linear model has a
continuous distribution of Raw characterized by the mean Raw and the
standard deviation of Raw (SDR). Lung mechanics were compared with
tissue strip mechanics at frequencies and operating stresses comparable
to those during lung impedance measurements. The hysteresivity ( )
was calculated as tissue damping/elastance. We found that 1 )
airway and tissue parameters were different in the IL than in the CC
and OC conditions; 2 ) SDR was lowest in the IL; and
3 ) in IL at low transpulmonary pressure was similar to
in the tissue strip. We conclude that is primarily determined
by lung connective tissue, and its elevated estimates from impedance
data in the CC and OC conditions are a consequence of compartment-like
heterogeneity being greater in CC and OC conditions than in the IL.
tissue resistance; tissue elastance; configuration; compartmental
behavior |
| doi_str_mv | 10.1152/jappl.2001.91.2.737 |
| format | Article |
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Boston 02215; and 2 Division of Pulmonary and Critical Care
Medicine, Brigham and Women's Hospital, Boston, Massachusetts
02115
We measured lung impedance in rats in closed
chest (CC), open chest (OC), and isolated lungs (IL) at four
transpulmonary pressures with a optimal ventilator waveform.
Data were analyzed with an homogeneous linear or an inhomogeneous
linear model. Both models include tissue damping and elastance and
airway inertance. The homogeneous linear model includes airway
resistance (Raw), whereas the inhomogeneous linear model has a
continuous distribution of Raw characterized by the mean Raw and the
standard deviation of Raw (SDR). Lung mechanics were compared with
tissue strip mechanics at frequencies and operating stresses comparable
to those during lung impedance measurements. The hysteresivity ( )
was calculated as tissue damping/elastance. We found that 1 )
airway and tissue parameters were different in the IL than in the CC
and OC conditions; 2 ) SDR was lowest in the IL; and
3 ) in IL at low transpulmonary pressure was similar to
in the tissue strip. We conclude that is primarily determined
by lung connective tissue, and its elevated estimates from impedance
data in the CC and OC conditions are a consequence of compartment-like
heterogeneity being greater in CC and OC conditions than in the IL.
tissue resistance; tissue elastance; configuration; compartmental
behavior</description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/jappl.2001.91.2.737</identifier><identifier>PMID: 11457789</identifier><identifier>CODEN: JAPHEV</identifier><language>eng</language><publisher>Bethesda, MD: Am Physiological Soc</publisher><subject>Air breathing ; Airway Resistance - physiology ; Animals ; Biological and medical sciences ; Elasticity ; Fundamental and applied biological sciences. Psychology ; In Vitro Techniques ; Lung - physiology ; Lungs ; Male ; Mathematics ; Models, Biological ; Pressure ; Rats ; Rats, Sprague-Dawley ; Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics ; Rodents ; Stress, Mechanical ; Tissues ; Vertebrates: respiratory system</subject><ispartof>Journal of applied physiology (1985), 2001-08, Vol.91 (2), p.737-747</ispartof><rights>2002 INIST-CNRS</rights><rights>Copyright American Physiological Society Aug 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c500t-af9d9325e9cfb353788e95f56ef8980aa1664bd6b7e9f94fe16ce7c57363d5333</citedby><cites>FETCH-LOGICAL-c500t-af9d9325e9cfb353788e95f56ef8980aa1664bd6b7e9f94fe16ce7c57363d5333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,3043,27933,27934</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14073081$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11457789$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sakai, Hiroaki</creatorcontrib><creatorcontrib>Ingenito, Edward P</creatorcontrib><creatorcontrib>Mora, Rene</creatorcontrib><creatorcontrib>Abbay, Senay</creatorcontrib><creatorcontrib>Cavalcante, Francisco S. A</creatorcontrib><creatorcontrib>Lutchen, Kenneth R</creatorcontrib><creatorcontrib>Suki, Bela</creatorcontrib><title>Hysteresivity of the lung and tissue strip in the normal rat: effects of heterogeneities</title><title>Journal of applied physiology (1985)</title><addtitle>J Appl Physiol (1985)</addtitle><description>1 Department of Biomedical Engineering, Boston University,
Boston 02215; and 2 Division of Pulmonary and Critical Care
Medicine, Brigham and Women's Hospital, Boston, Massachusetts
02115
We measured lung impedance in rats in closed
chest (CC), open chest (OC), and isolated lungs (IL) at four
transpulmonary pressures with a optimal ventilator waveform.
Data were analyzed with an homogeneous linear or an inhomogeneous
linear model. Both models include tissue damping and elastance and
airway inertance. The homogeneous linear model includes airway
resistance (Raw), whereas the inhomogeneous linear model has a
continuous distribution of Raw characterized by the mean Raw and the
standard deviation of Raw (SDR). Lung mechanics were compared with
tissue strip mechanics at frequencies and operating stresses comparable
to those during lung impedance measurements. The hysteresivity ( )
was calculated as tissue damping/elastance. We found that 1 )
airway and tissue parameters were different in the IL than in the CC
and OC conditions; 2 ) SDR was lowest in the IL; and
3 ) in IL at low transpulmonary pressure was similar to
in the tissue strip. We conclude that is primarily determined
by lung connective tissue, and its elevated estimates from impedance
data in the CC and OC conditions are a consequence of compartment-like
heterogeneity being greater in CC and OC conditions than in the IL.
tissue resistance; tissue elastance; configuration; compartmental
behavior</description><subject>Air breathing</subject><subject>Airway Resistance - physiology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Elasticity</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>In Vitro Techniques</subject><subject>Lung - physiology</subject><subject>Lungs</subject><subject>Male</subject><subject>Mathematics</subject><subject>Models, Biological</subject><subject>Pressure</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics</subject><subject>Rodents</subject><subject>Stress, Mechanical</subject><subject>Tissues</subject><subject>Vertebrates: respiratory system</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kNGK1DAUhoMo7rj6BIIEQb1qTZqmSbyTxXWFBW9W8C5k0pNphkxbk1Tt25vZHRkQvDoX5_v_c_gQeklJTSlv3u_NPIe6IYTWitZNLZh4hDZl01S0I_Qx2kjBSSW4FBfoWUr7QrYtp0_RBaUtF0KqDfp-s6YMEZL_6fOKJ4fzADgs4w6bscfZp7QATjn6GfvxfjlO8WACjiZ_wOAc2JyOuQFKz7SDEXz2kJ6jJ86EBC9O8xJ9u_50d3VT3X79_OXq421lOSG5Mk71ijUclHVbxpmQEhR3vAMnlSTG0K5rt323FaCcah3QzoKwXLCO9ZwxdonePvTOcfqxQMr64JOFEMwI05K0oKRVVIoCvv4H3E9LHMtvumkaykmRVSD2ANk4pRTB6Tn6g4mrpkQfret76_poXSuqG12sl9SrU_WyPUB_zpw0F-DNCTDJmuCiGa1PZ64lghFJz-cHvxt--Qh6HtbkpzDtVn29hHAHv_Pxhb-n9dy7knr3_1SBz4_-AQoYrMc</recordid><startdate>20010801</startdate><enddate>20010801</enddate><creator>Sakai, Hiroaki</creator><creator>Ingenito, Edward P</creator><creator>Mora, Rene</creator><creator>Abbay, Senay</creator><creator>Cavalcante, Francisco S. A</creator><creator>Lutchen, Kenneth R</creator><creator>Suki, Bela</creator><general>Am Physiological Soc</general><general>American Physiological Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20010801</creationdate><title>Hysteresivity of the lung and tissue strip in the normal rat: effects of heterogeneities</title><author>Sakai, Hiroaki ; Ingenito, Edward P ; Mora, Rene ; Abbay, Senay ; Cavalcante, Francisco S. A ; Lutchen, Kenneth R ; Suki, Bela</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c500t-af9d9325e9cfb353788e95f56ef8980aa1664bd6b7e9f94fe16ce7c57363d5333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Air breathing</topic><topic>Airway Resistance - physiology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Elasticity</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>In Vitro Techniques</topic><topic>Lung - physiology</topic><topic>Lungs</topic><topic>Male</topic><topic>Mathematics</topic><topic>Models, Biological</topic><topic>Pressure</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics</topic><topic>Rodents</topic><topic>Stress, Mechanical</topic><topic>Tissues</topic><topic>Vertebrates: respiratory system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sakai, Hiroaki</creatorcontrib><creatorcontrib>Ingenito, Edward P</creatorcontrib><creatorcontrib>Mora, Rene</creatorcontrib><creatorcontrib>Abbay, Senay</creatorcontrib><creatorcontrib>Cavalcante, Francisco S. 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A</au><au>Lutchen, Kenneth R</au><au>Suki, Bela</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hysteresivity of the lung and tissue strip in the normal rat: effects of heterogeneities</atitle><jtitle>Journal of applied physiology (1985)</jtitle><addtitle>J Appl Physiol (1985)</addtitle><date>2001-08-01</date><risdate>2001</risdate><volume>91</volume><issue>2</issue><spage>737</spage><epage>747</epage><pages>737-747</pages><issn>8750-7587</issn><eissn>1522-1601</eissn><coden>JAPHEV</coden><abstract>1 Department of Biomedical Engineering, Boston University,
Boston 02215; and 2 Division of Pulmonary and Critical Care
Medicine, Brigham and Women's Hospital, Boston, Massachusetts
02115
We measured lung impedance in rats in closed
chest (CC), open chest (OC), and isolated lungs (IL) at four
transpulmonary pressures with a optimal ventilator waveform.
Data were analyzed with an homogeneous linear or an inhomogeneous
linear model. Both models include tissue damping and elastance and
airway inertance. The homogeneous linear model includes airway
resistance (Raw), whereas the inhomogeneous linear model has a
continuous distribution of Raw characterized by the mean Raw and the
standard deviation of Raw (SDR). Lung mechanics were compared with
tissue strip mechanics at frequencies and operating stresses comparable
to those during lung impedance measurements. The hysteresivity ( )
was calculated as tissue damping/elastance. We found that 1 )
airway and tissue parameters were different in the IL than in the CC
and OC conditions; 2 ) SDR was lowest in the IL; and
3 ) in IL at low transpulmonary pressure was similar to
in the tissue strip. We conclude that is primarily determined
by lung connective tissue, and its elevated estimates from impedance
data in the CC and OC conditions are a consequence of compartment-like
heterogeneity being greater in CC and OC conditions than in the IL.
tissue resistance; tissue elastance; configuration; compartmental
behavior</abstract><cop>Bethesda, MD</cop><pub>Am Physiological Soc</pub><pmid>11457789</pmid><doi>10.1152/jappl.2001.91.2.737</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 8750-7587 |
| ispartof | Journal of applied physiology (1985), 2001-08, Vol.91 (2), p.737-747 |
| issn | 8750-7587 1522-1601 |
| language | eng |
| recordid | cdi_pubmed_primary_11457789 |
| source | MEDLINE; American Physiological Society Paid; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Air breathing Airway Resistance - physiology Animals Biological and medical sciences Elasticity Fundamental and applied biological sciences. Psychology In Vitro Techniques Lung - physiology Lungs Male Mathematics Models, Biological Pressure Rats Rats, Sprague-Dawley Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics Rodents Stress, Mechanical Tissues Vertebrates: respiratory system |
| title | Hysteresivity of the lung and tissue strip in the normal rat: effects of heterogeneities |
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