In Vitro and in Vivo Properties of Novel Nucleoside Transport Inhibitors with Improved Pharmacological Properties That Potentiate Antifolate Activity

The activity of antimetabolite inhibitors of de novo deoxyribonucleotide biosynthesis can be compromised by the salvage of extracellular preformed nucleosides and nucleobases. Dipyridamole (DP) is a nucleoside transport inhibitor that has been used clinically in an attempt to increase antimetabolite...

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Veröffentlicht in:	Clinical cancer research 2001-07, Vol.7 (7), p.2105-2113
Hauptverfasser:	SMITH, Peter G, THOMAS, Huw D, BARLOW, Hannah C, GRIFFIN, Roger J, GOLDING, Bernard T, CALVERT, A. Hilary, NEWELL, David R, CURTIN, Nicola J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Carrier Proteins - antagonists & inhibitors Carrier Proteins - metabolism Cell Division - drug effects Chemotherapy Dipyridamole - chemistry Dipyridamole - pharmacokinetics Dipyridamole - pharmacology Dose-Response Relationship, Drug Drug Synergism Female Folic Acid Antagonists - pharmacology Glutamates - pharmacology Guanine - analogs & derivatives Guanine - pharmacology Humans Hypoxanthine - pharmacology Liver - metabolism Medical sciences Membrane Proteins - antagonists & inhibitors Membrane Proteins - metabolism Mice Mice, Inbred BALB C Nucleoside Transport Proteins Orosomucoid - pharmacology Pemetrexed Pharmacology. Drug treatments Tetrahydrofolates - pharmacology Thymidine - metabolism Time Factors Tritium Tumor Cells, Cultured
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