Evaluation of the hypothalamic-pituitary-adrenal axis in children with leukemia before and after 6 weeks of high-dose glucocorticoid therapy

Among the adverse effects arising from chronic high-dose glucocorticoid treatment, adrenal insufficiency secondary to suppression of the hypothalamic-pituitary-adrenal (HPA) axis is a cause for concern. Glucocorticoid-induced adrenal suppression is related to the duration of therapy, type of steroid...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2001-07, Vol.86 (7), p.2993-2996
Hauptverfasser:	KUPERMAN, Hilton, DAMIANI, Durval, CHROUSOS, George P, DICHTCHEKENIAN, Vaê, DELLA MANNA, Thais, ODONE, Vicente FILHO, SETIAN, Nuvarte
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Glands - drug effects Adrenal Glands - physiopathology Adrenal Insufficiency - chemically induced Adrenocorticotropic Hormone - blood Biological and medical sciences Child Child, Preschool Corticotropin-Releasing Hormone Dexamethasone - administration & dosage Dexamethasone - adverse effects Dexamethasone - therapeutic use Drug toxicity and drugs side effects treatment Female Glucocorticoids - administration & dosage Glucocorticoids - adverse effects Glucocorticoids - therapeutic use Humans Hydrocortisone - blood Hypothalamus - drug effects Hypothalamus - physiopathology Infant Kinetics Male Medical sciences Miscellaneous (drug allergy, mutagens, teratogens...) Pharmacology. Drug treatments Pituitary Gland - drug effects Pituitary Gland - physiopathology Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor Cell Lymphoblastic Leukemia-Lymphoma - physiopathology
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