Influence of verapamil on the efflux and metabolism of 14C moxidectin in cultured rat hepatocytes

Moxidectin (MOX) is an antiparasitic drug widely used in cattle, sheep and companion animals. As a result of the implication of cytochrome P450 3 A in the metabolism of MOX and the role of competitor substrates of P‐glycoprotein (Pgp) in modification of the bioavailability of endectocides, we studie...

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Veröffentlicht in:	Journal of veterinary pharmacology and therapeutics 2001-06, Vol.24 (3), p.171-177
Hauptverfasser:	Dupuy, J., Larrieu, G., Sutra, J. F., Eeckhoutte, C., Alvinerie, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anthelmintics - pharmacokinetics Anti-Bacterial Agents - pharmacokinetics Area Under Curve ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism Carbon Radioisotopes - pharmacokinetics Drug Interactions Hepatocytes - metabolism Macrolides Male Microsomes, Liver - metabolism Rats Rats, Sprague-Dawley Verapamil - pharmacology
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