GAPDH knockdown rescues mesencephalic dopaminergic neurons from MPP+-induced apoptosis

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH; EC 1.2.1.12) has a number of diverse functions apart from glycolytic function. We explored the possible involvement of GAPDH in 1-methyl-4-phenylpyridinium (MPP)-induced death of mesencephalic dopaminergic neurons (MDNs) in culture. MPP (10 and 20 μM,...

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Veröffentlicht in:	Neuroreport 2001-07, Vol.12 (9), p.2049-2052
Hauptverfasser:	Fukuhara, Yoko, Takeshima, Takao, Kashiwaya, Yoshihiro, Shimoda, Kotaro, Ishitani, Ryoichi, Nakashima, Kenji
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-4-phenylpyridinium - pharmacology Animals Apoptosis - drug effects Apoptosis - physiology Cell Survival - drug effects Cell Survival - physiology Cells, Cultured - cytology Cells, Cultured - drug effects Cells, Cultured - enzymology Dopamine - metabolism Fetus Glyceraldehyde-3-Phosphate Dehydrogenases - antagonists & inhibitors Glyceraldehyde-3-Phosphate Dehydrogenases - genetics Herbicides - pharmacology Immunohistochemistry Microtubule-Associated Proteins - metabolism Neurons - drug effects Neurons - enzymology Neurons - pathology Oligonucleotides, Antisense - pharmacology Parkinson Disease - enzymology Parkinson Disease - physiopathology Parkinson Disease, Secondary - chemically induced Rats Rats, Sprague-Dawley Substantia Nigra - drug effects Substantia Nigra - enzymology Substantia Nigra - pathology Tyrosine 3-Monooxygenase - metabolism
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