A novel approach for studying endogenous abeta processing using cultured primary neurons isolated from APP transgenic mice

The central component of senile amyloid plaques in Alzheimer's disease (AD) is the beta-amyloid peptide (Abeta), derived from proteolytic processing of the amyloid precursor protein (APP). In this study, we developed an in vitro model to measure and identify soluble Abeta from primary cortical...

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Veröffentlicht in:	Experimental neurology 2001-07, Vol.170 (1), p.186
Hauptverfasser:	Qiu, Z, Naten, D L, Liston, J C, Yess, J, Rebeck, G W
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha 1-Antichymotrypsin - pharmacology alpha 1-Antitrypsin - pharmacology Amyloid beta-Peptides - analysis Amyloid beta-Peptides - metabolism Amyloid beta-Protein Precursor - genetics Amyloid beta-Protein Precursor - metabolism Animals Blotting, Western Cells, Cultured Culture Media, Conditioned - chemistry Disease Models, Animal Enzyme-Linked Immunosorbent Assay Humans Mice Mice, Transgenic Neurons - cytology Neurons - drug effects Neurons - metabolism Protein Processing, Post-Translational Sensitivity and Specificity Tetradecanoylphorbol Acetate - pharmacology
Online-Zugang:	Volltext
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