Adjuvant Postoperative 5-Fluorouracil Chemotherapy Combined with Pelvic Radiation for Rectal Cancer: Results from an Asian Population
Prospective randomized clinical trials have shown the effectiveness of combined adjuvant 5-fluorouracil-based chemotherapy and radiotherapy after surgical resection of rectal cancer. To assess toxicity of this therapy, prospective data were collected from 236 Asian rectal cancer patients treated wit...
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| Veröffentlicht in: | Cancer investigation 2001, Vol.19 (4), p.340-345 |
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| creator | Au, Elizabeth Koo, Wen-Hsin Lee, Kim-Shang Chua, Eu-Jin Soo, Kee-Chee Seow-Choen, Francis Low, Cheng-Hock Ng, Boon-Keng Hoe, Michael |
| description | Prospective randomized clinical trials have shown the effectiveness of combined adjuvant 5-fluorouracil-based chemotherapy and radiotherapy after surgical resection of rectal cancer. To assess toxicity of this therapy, prospective data were collected from 236 Asian rectal cancer patients treated with combined 5-fluorouracil-based chemotherapy and radiotherapy after surgery. Almost 82% of patients completed planned therapy. Grade 3 and 4 diarrhea, stomatitis, and granulocytopenia occurred in approximately 18-21% of patients. There were two treatment-related deaths from granulocytopenia and sepsis. With median follow-up of 3.5 years, median disease-free and overall survival was 75 and 88 months, respectively. In conclusion, combined adjuvant 5-fluorouracil-based chemotherapy and radiotherapy after surgical resection of rectal cancer is tolerable in Asian patients with moderate toxicity. |
| doi_str_mv | 10.1081/CNV-100103128 |
| format | Article |
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To assess toxicity of this therapy, prospective data were collected from 236 Asian rectal cancer patients treated with combined 5-fluorouracil-based chemotherapy and radiotherapy after surgery. Almost 82% of patients completed planned therapy. Grade 3 and 4 diarrhea, stomatitis, and granulocytopenia occurred in approximately 18-21% of patients. There were two treatment-related deaths from granulocytopenia and sepsis. With median follow-up of 3.5 years, median disease-free and overall survival was 75 and 88 months, respectively. In conclusion, combined adjuvant 5-fluorouracil-based chemotherapy and radiotherapy after surgical resection of rectal cancer is tolerable in Asian patients with moderate toxicity.</description><identifier>ISSN: 0735-7907</identifier><identifier>EISSN: 1532-4192</identifier><identifier>DOI: 10.1081/CNV-100103128</identifier><identifier>PMID: 11405173</identifier><identifier>CODEN: CINVD7</identifier><language>eng</language><publisher>New York, NY: Informa UK Ltd</publisher><subject>5-fluorouracil ; Adenocarcinoma - drug therapy ; Adenocarcinoma - mortality ; Adenocarcinoma - radiotherapy ; Adenocarcinoma - surgery ; Adjuvant therapy ; Adult ; Aged ; Aged, 80 and over ; Agranulocytosis - chemically induced ; Agranulocytosis - mortality ; Antimetabolites, Antineoplastic - adverse effects ; Antimetabolites, Antineoplastic - therapeutic use ; Antineoplastic agents ; Biological and medical sciences ; Chemotherapy ; Chemotherapy, Adjuvant ; Combined Modality Therapy ; Combined treatments (chemotherapy of immunotherapy associated with an other treatment) ; Diarrhea - chemically induced ; Disease-Free Survival ; Drug Evaluation ; Female ; Fluorouracil - adverse effects ; Fluorouracil - therapeutic use ; Humans ; Leucovorin - therapeutic use ; Life Tables ; Lymph Node Excision ; Male ; Medical sciences ; Middle Aged ; Neoplasm Metastasis ; Pharmacology. Drug treatments ; Postoperative Period ; Prospective Studies ; Radiotherapy ; Radiotherapy, Adjuvant ; Rectal cancer ; Rectal Neoplasms - drug therapy ; Rectal Neoplasms - mortality ; Rectal Neoplasms - radiotherapy ; Rectal Neoplasms - surgery ; Sepsis - etiology ; Sepsis - mortality ; Singapore - epidemiology ; Stomatitis - chemically induced ; Survival Analysis</subject><ispartof>Cancer investigation, 2001, Vol.19 (4), p.340-345</ispartof><rights>2001 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2001</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c371t-d8923c9080576dd4c4b2673c1579b91a77c64cfe3dade7298fd042f15a29c86f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1081/CNV-100103128$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1081/CNV-100103128$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,780,784,4024,27923,27924,27925,59647,59753,60436,60542,61221,61256,61402,61437</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1002528$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11405173$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Au, Elizabeth</creatorcontrib><creatorcontrib>Koo, Wen-Hsin</creatorcontrib><creatorcontrib>Lee, Kim-Shang</creatorcontrib><creatorcontrib>Chua, Eu-Jin</creatorcontrib><creatorcontrib>Soo, Kee-Chee</creatorcontrib><creatorcontrib>Seow-Choen, Francis</creatorcontrib><creatorcontrib>Low, Cheng-Hock</creatorcontrib><creatorcontrib>Ng, Boon-Keng</creatorcontrib><creatorcontrib>Hoe, Michael</creatorcontrib><title>Adjuvant Postoperative 5-Fluorouracil Chemotherapy Combined with Pelvic Radiation for Rectal Cancer: Results from an Asian Population</title><title>Cancer investigation</title><addtitle>Cancer Invest</addtitle><description>Prospective randomized clinical trials have shown the effectiveness of combined adjuvant 5-fluorouracil-based chemotherapy and radiotherapy after surgical resection of rectal cancer. To assess toxicity of this therapy, prospective data were collected from 236 Asian rectal cancer patients treated with combined 5-fluorouracil-based chemotherapy and radiotherapy after surgery. Almost 82% of patients completed planned therapy. Grade 3 and 4 diarrhea, stomatitis, and granulocytopenia occurred in approximately 18-21% of patients. There were two treatment-related deaths from granulocytopenia and sepsis. With median follow-up of 3.5 years, median disease-free and overall survival was 75 and 88 months, respectively. In conclusion, combined adjuvant 5-fluorouracil-based chemotherapy and radiotherapy after surgical resection of rectal cancer is tolerable in Asian patients with moderate toxicity.</description><subject>5-fluorouracil</subject><subject>Adenocarcinoma - drug therapy</subject><subject>Adenocarcinoma - mortality</subject><subject>Adenocarcinoma - radiotherapy</subject><subject>Adenocarcinoma - surgery</subject><subject>Adjuvant therapy</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Agranulocytosis - chemically induced</subject><subject>Agranulocytosis - mortality</subject><subject>Antimetabolites, Antineoplastic - adverse effects</subject><subject>Antimetabolites, Antineoplastic - therapeutic use</subject><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Chemotherapy</subject><subject>Chemotherapy, Adjuvant</subject><subject>Combined Modality Therapy</subject><subject>Combined treatments (chemotherapy of immunotherapy associated with an other treatment)</subject><subject>Diarrhea - chemically induced</subject><subject>Disease-Free Survival</subject><subject>Drug Evaluation</subject><subject>Female</subject><subject>Fluorouracil - adverse effects</subject><subject>Fluorouracil - therapeutic use</subject><subject>Humans</subject><subject>Leucovorin - therapeutic use</subject><subject>Life Tables</subject><subject>Lymph Node Excision</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Metastasis</subject><subject>Pharmacology. Drug treatments</subject><subject>Postoperative Period</subject><subject>Prospective Studies</subject><subject>Radiotherapy</subject><subject>Radiotherapy, Adjuvant</subject><subject>Rectal cancer</subject><subject>Rectal Neoplasms - drug therapy</subject><subject>Rectal Neoplasms - mortality</subject><subject>Rectal Neoplasms - radiotherapy</subject><subject>Rectal Neoplasms - surgery</subject><subject>Sepsis - etiology</subject><subject>Sepsis - mortality</subject><subject>Singapore - epidemiology</subject><subject>Stomatitis - chemically induced</subject><subject>Survival Analysis</subject><issn>0735-7907</issn><issn>1532-4192</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kctu1DAYhS0EokNhyRZ5wTbFl3icsBtFlCJVMKqAbfSPL4pHThzZzlTzALw3pjPcFt3Ysvydo9-fEXpNyRUlDX3Xff5eUUIo4ZQ1T9CKCs6qmrbsKVoRyUUlWyIv0IuU9oVqmBTP0QWlNRFU8hX6sdH75QBTxtuQcphNhOwOBovq2i8hhiWCch53gxlDHsrtfMRdGHduMhrfuzzgrfEHp_AdaFeiYcI2RHxnVIYSg0mZ-L4c0-JzwjaGEcOEN8mVdRvmxT9kXqJnFnwyr877Jfp2_eFrd1Pdfvn4qdvcVopLmivdtIyrljREyLXWtap3bC25okK2u5aClGpdK2u4Bm0kaxurSc0sFcBa1awtv0TVqVfFkFI0tp-jGyEee0r6Xzr7orP_o7Pwb078vOxGo__SZ38FeHsGICnwNpYHu_RPK2Hioac5YW4qdka4D9HrPsPRh_g7wx8bQf4XHQz4PCiIpt-X35mKrkeG_wnj0qMd</recordid><startdate>2001</startdate><enddate>2001</enddate><creator>Au, Elizabeth</creator><creator>Koo, Wen-Hsin</creator><creator>Lee, Kim-Shang</creator><creator>Chua, Eu-Jin</creator><creator>Soo, Kee-Chee</creator><creator>Seow-Choen, Francis</creator><creator>Low, Cheng-Hock</creator><creator>Ng, Boon-Keng</creator><creator>Hoe, Michael</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Informa Healthcare</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>2001</creationdate><title>Adjuvant Postoperative 5-Fluorouracil Chemotherapy Combined with Pelvic Radiation for Rectal Cancer: Results from an Asian Population</title><author>Au, Elizabeth ; Koo, Wen-Hsin ; Lee, Kim-Shang ; Chua, Eu-Jin ; Soo, Kee-Chee ; Seow-Choen, Francis ; Low, Cheng-Hock ; Ng, Boon-Keng ; Hoe, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-d8923c9080576dd4c4b2673c1579b91a77c64cfe3dade7298fd042f15a29c86f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>5-fluorouracil</topic><topic>Adenocarcinoma - drug therapy</topic><topic>Adenocarcinoma - mortality</topic><topic>Adenocarcinoma - radiotherapy</topic><topic>Adenocarcinoma - surgery</topic><topic>Adjuvant therapy</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Agranulocytosis - chemically induced</topic><topic>Agranulocytosis - mortality</topic><topic>Antimetabolites, Antineoplastic - adverse effects</topic><topic>Antimetabolites, Antineoplastic - therapeutic use</topic><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>Chemotherapy</topic><topic>Chemotherapy, Adjuvant</topic><topic>Combined Modality Therapy</topic><topic>Combined treatments (chemotherapy of immunotherapy associated with an other treatment)</topic><topic>Diarrhea - chemically induced</topic><topic>Disease-Free Survival</topic><topic>Drug Evaluation</topic><topic>Female</topic><topic>Fluorouracil - adverse effects</topic><topic>Fluorouracil - therapeutic use</topic><topic>Humans</topic><topic>Leucovorin - therapeutic use</topic><topic>Life Tables</topic><topic>Lymph Node Excision</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Metastasis</topic><topic>Pharmacology. Drug treatments</topic><topic>Postoperative Period</topic><topic>Prospective Studies</topic><topic>Radiotherapy</topic><topic>Radiotherapy, Adjuvant</topic><topic>Rectal cancer</topic><topic>Rectal Neoplasms - drug therapy</topic><topic>Rectal Neoplasms - mortality</topic><topic>Rectal Neoplasms - radiotherapy</topic><topic>Rectal Neoplasms - surgery</topic><topic>Sepsis - etiology</topic><topic>Sepsis - mortality</topic><topic>Singapore - epidemiology</topic><topic>Stomatitis - chemically induced</topic><topic>Survival Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Au, Elizabeth</creatorcontrib><creatorcontrib>Koo, Wen-Hsin</creatorcontrib><creatorcontrib>Lee, Kim-Shang</creatorcontrib><creatorcontrib>Chua, Eu-Jin</creatorcontrib><creatorcontrib>Soo, Kee-Chee</creatorcontrib><creatorcontrib>Seow-Choen, Francis</creatorcontrib><creatorcontrib>Low, Cheng-Hock</creatorcontrib><creatorcontrib>Ng, Boon-Keng</creatorcontrib><creatorcontrib>Hoe, Michael</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Cancer investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Au, Elizabeth</au><au>Koo, Wen-Hsin</au><au>Lee, Kim-Shang</au><au>Chua, Eu-Jin</au><au>Soo, Kee-Chee</au><au>Seow-Choen, Francis</au><au>Low, Cheng-Hock</au><au>Ng, Boon-Keng</au><au>Hoe, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adjuvant Postoperative 5-Fluorouracil Chemotherapy Combined with Pelvic Radiation for Rectal Cancer: Results from an Asian Population</atitle><jtitle>Cancer investigation</jtitle><addtitle>Cancer Invest</addtitle><date>2001</date><risdate>2001</risdate><volume>19</volume><issue>4</issue><spage>340</spage><epage>345</epage><pages>340-345</pages><issn>0735-7907</issn><eissn>1532-4192</eissn><coden>CINVD7</coden><abstract>Prospective randomized clinical trials have shown the effectiveness of combined adjuvant 5-fluorouracil-based chemotherapy and radiotherapy after surgical resection of rectal cancer. To assess toxicity of this therapy, prospective data were collected from 236 Asian rectal cancer patients treated with combined 5-fluorouracil-based chemotherapy and radiotherapy after surgery. Almost 82% of patients completed planned therapy. Grade 3 and 4 diarrhea, stomatitis, and granulocytopenia occurred in approximately 18-21% of patients. There were two treatment-related deaths from granulocytopenia and sepsis. With median follow-up of 3.5 years, median disease-free and overall survival was 75 and 88 months, respectively. In conclusion, combined adjuvant 5-fluorouracil-based chemotherapy and radiotherapy after surgical resection of rectal cancer is tolerable in Asian patients with moderate toxicity.</abstract><cop>New York, NY</cop><pub>Informa UK Ltd</pub><pmid>11405173</pmid><doi>10.1081/CNV-100103128</doi><tpages>6</tpages></addata></record> |
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| ispartof | Cancer investigation, 2001, Vol.19 (4), p.340-345 |
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| subjects | 5-fluorouracil Adenocarcinoma - drug therapy Adenocarcinoma - mortality Adenocarcinoma - radiotherapy Adenocarcinoma - surgery Adjuvant therapy Adult Aged Aged, 80 and over Agranulocytosis - chemically induced Agranulocytosis - mortality Antimetabolites, Antineoplastic - adverse effects Antimetabolites, Antineoplastic - therapeutic use Antineoplastic agents Biological and medical sciences Chemotherapy Chemotherapy, Adjuvant Combined Modality Therapy Combined treatments (chemotherapy of immunotherapy associated with an other treatment) Diarrhea - chemically induced Disease-Free Survival Drug Evaluation Female Fluorouracil - adverse effects Fluorouracil - therapeutic use Humans Leucovorin - therapeutic use Life Tables Lymph Node Excision Male Medical sciences Middle Aged Neoplasm Metastasis Pharmacology. Drug treatments Postoperative Period Prospective Studies Radiotherapy Radiotherapy, Adjuvant Rectal cancer Rectal Neoplasms - drug therapy Rectal Neoplasms - mortality Rectal Neoplasms - radiotherapy Rectal Neoplasms - surgery Sepsis - etiology Sepsis - mortality Singapore - epidemiology Stomatitis - chemically induced Survival Analysis |
| title | Adjuvant Postoperative 5-Fluorouracil Chemotherapy Combined with Pelvic Radiation for Rectal Cancer: Results from an Asian Population |
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