Caspases: Conductors of the Cell Death Machinery in Lymphoma Cells
The present review focuses on recent insights into the regulation of caspases by other components of the apoptotic pathway, including the mechanisms by which caspase activation influence the death of lymphoma cells. In the light of our recent findings and similar observations of other investigators,...
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| Veröffentlicht in: | Leukemia & lymphoma 2001-04, Vol.41 (3-4), p.247-253 |
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| container_issue | 3-4 |
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| container_title | Leukemia & lymphoma |
| container_volume | 41 |
| creator | Dales, Jean Philippe Palmerini, Fabienne Devilard, Elisabeth Hassoun, Jacques Birg, FranÇOise Xerri, Luc |
| description | The present review focuses on recent insights into the regulation of caspases by other components of the apoptotic pathway, including the mechanisms by which caspase activation influence the death of lymphoma cells. In the light of our recent findings and similar observations of other investigators, it is likely that lymphoma cells possess the complete caspase machinery required for the apoptotic process. Inhibition of caspases activation appears as a potential mechanism to explain apoptotic defects of malignant B-cells, and thus may constitute the basis for new cancer therapies. |
| doi_str_mv | 10.3109/10428190109057980 |
| format | Article |
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In the light of our recent findings and similar observations of other investigators, it is likely that lymphoma cells possess the complete caspase machinery required for the apoptotic process. Inhibition of caspases activation appears as a potential mechanism to explain apoptotic defects of malignant B-cells, and thus may constitute the basis for new cancer therapies.</description><subject>Apoptosis - drug effects</subject><subject>Carrier Proteins - pharmacology</subject><subject>CASP8 and FADD-Like Apoptosis Regulating Protein</subject><subject>Caspase Inhibitors</subject><subject>caspases</subject><subject>Caspases - metabolism</subject><subject>Caspases - physiology</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Fas-induced apoptosis</subject><subject>FLIP</subject><subject>Humans</subject><subject>IAP</subject><subject>Intracellular Signaling Peptides and Proteins</subject><subject>Lymphoma, Non-Hodgkin - enzymology</subject><subject>Lymphoma, Non-Hodgkin - pathology</subject><subject>Non Hodgkin's lymphomas</subject><issn>1042-8194</issn><issn>1029-2403</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLxDAUhYMovn-AG-nKXfUmTdtE3Wh9wogbXZc7edAObTMmLTL_3o4zICLq6p7Fd849HEKOKJwmFOQZBc4ElTBqSHMpYIPsUmAyZhySzaXmLB4BvkP2QpgBQCoztk12KE1ykSZil1wXGOYYTDiPCtfpQfXOh8jZqK9MVJimiW4M9lX0hKqqO-MXUd1Fk0U7r1yLn0A4IFsWm2AO13efvN7dvhQP8eT5_rG4msSKJ0kfIxrOaE6nlkmdC8s14tRCJjMrOSiTaS4yTalkTGmjIcupVFbz3AojgKXJPjlZ5c69extM6Mu2DmpsgJ1xQyhzECLNx1__gVTQLBEpjCBdgcq7ELyx5dzXLfpFSaFcLlz-WHj0HK_Dh2lr9JdjPekIXK6AurPOt_jufKPLHheN89Zjp-qwzP49_-KbvTLY9JVCb8qZG3w3LvxHuw8X7poN</recordid><startdate>20010401</startdate><enddate>20010401</enddate><creator>Dales, Jean Philippe</creator><creator>Palmerini, Fabienne</creator><creator>Devilard, Elisabeth</creator><creator>Hassoun, Jacques</creator><creator>Birg, FranÇOise</creator><creator>Xerri, Luc</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20010401</creationdate><title>Caspases: Conductors of the Cell Death Machinery in Lymphoma Cells</title><author>Dales, Jean Philippe ; Palmerini, Fabienne ; Devilard, Elisabeth ; Hassoun, Jacques ; Birg, FranÇOise ; Xerri, Luc</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c433t-aae42171bf29d78f4daabf0696f940ce6d486d11922cded06719cfd47f8e80253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Apoptosis - drug effects</topic><topic>Carrier Proteins - pharmacology</topic><topic>CASP8 and FADD-Like Apoptosis Regulating Protein</topic><topic>Caspase Inhibitors</topic><topic>caspases</topic><topic>Caspases - metabolism</topic><topic>Caspases - physiology</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Fas-induced apoptosis</topic><topic>FLIP</topic><topic>Humans</topic><topic>IAP</topic><topic>Intracellular Signaling Peptides and Proteins</topic><topic>Lymphoma, Non-Hodgkin - enzymology</topic><topic>Lymphoma, Non-Hodgkin - pathology</topic><topic>Non Hodgkin's lymphomas</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dales, Jean Philippe</creatorcontrib><creatorcontrib>Palmerini, Fabienne</creatorcontrib><creatorcontrib>Devilard, Elisabeth</creatorcontrib><creatorcontrib>Hassoun, Jacques</creatorcontrib><creatorcontrib>Birg, FranÇOise</creatorcontrib><creatorcontrib>Xerri, Luc</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Leukemia & lymphoma</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dales, Jean Philippe</au><au>Palmerini, Fabienne</au><au>Devilard, Elisabeth</au><au>Hassoun, Jacques</au><au>Birg, FranÇOise</au><au>Xerri, Luc</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Caspases: Conductors of the Cell Death Machinery in Lymphoma Cells</atitle><jtitle>Leukemia & lymphoma</jtitle><addtitle>Leuk Lymphoma</addtitle><date>2001-04-01</date><risdate>2001</risdate><volume>41</volume><issue>3-4</issue><spage>247</spage><epage>253</epage><pages>247-253</pages><issn>1042-8194</issn><eissn>1029-2403</eissn><abstract>The present review focuses on recent insights into the regulation of caspases by other components of the apoptotic pathway, including the mechanisms by which caspase activation influence the death of lymphoma cells. 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| identifier | ISSN: 1042-8194 |
| ispartof | Leukemia & lymphoma, 2001-04, Vol.41 (3-4), p.247-253 |
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| language | eng |
| recordid | cdi_pubmed_primary_11378538 |
| source | MEDLINE; Taylor & Francis:Master (3349 titles); Taylor & Francis Medical Library - CRKN |
| subjects | Apoptosis - drug effects Carrier Proteins - pharmacology CASP8 and FADD-Like Apoptosis Regulating Protein Caspase Inhibitors caspases Caspases - metabolism Caspases - physiology Enzyme Inhibitors - pharmacology Fas-induced apoptosis FLIP Humans IAP Intracellular Signaling Peptides and Proteins Lymphoma, Non-Hodgkin - enzymology Lymphoma, Non-Hodgkin - pathology Non Hodgkin's lymphomas |
| title | Caspases: Conductors of the Cell Death Machinery in Lymphoma Cells |
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