Nasal strips do not affect pulmonary gas exchange, anaerobic metabolism, or EIPH in exercising Thoroughbreds
Departments of Veterinary Clinical Medicine and Biosciences, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801 The present study was carried out to examine whether nasal strip application would improve the exercise-induced arterial hypoxemia and hyper...
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| Veröffentlicht in: | Journal of applied physiology (1985) 2001-06, Vol.90 (6), p.2378-2385 |
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| container_title | Journal of applied physiology (1985) |
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| creator | Goetz, Thomas E Manohar, Murli Hassan, Aslam S Baker, Gordon J |
| description | Departments of Veterinary Clinical Medicine and Biosciences,
College of Veterinary Medicine, University of Illinois at
Urbana-Champaign, Urbana, Illinois 61801
The present
study was carried out to examine whether nasal strip application would
improve the exercise-induced arterial hypoxemia and hypercapnia, diminish anaerobic metabolism, and modify the incidence of exercise-induced pulmonary hemorrhage (EIPH) in horses. Two sets of experiments, control and nasal strip experiments, were
carried out on seven healthy, sound, exercise-trained Thoroughbred horses in random order, 7 days apart. Simultaneous measurements of core
temperature, arterial and mixed venous blood gases/pH, and blood
lactate and ammonia concentrations were made at rest, during submaximal
and near-maximal exercise, and during recovery. In both treatments,
whereas submaximal exercise caused hyperventilation, near-maximal
exercise induced significant arterial hypoxemia, desaturation of Hb,
hypercapnia, and acidosis. However, O 2 content increased
significantly with exercise in both treatments, while the mixed venous
blood O 2 content decreased as O 2 extraction
increased. In both treatments, plasma ammonia and blood lactate
concentrations increased significantly with exercise. Statistically
significant differences between the control and the nasal strip
experiments could not be discerned, however. Also, all horses
experienced EIPH in both treatments. Thus our data indicated that
application of an external nasal dilator strip neither improved the
exercise-induced arterial hypoxemia and hypercapnia nor diminished
anaerobic metabolism or the incidence of EIPH in Thoroughbred horses
performing strenuous exercise.
nasal dilator strip; blood-gas tensions; lactate production; ammonia production; exercise-induced pulmonary hemorrhage |
| doi_str_mv | 10.1152/jappl.2001.90.6.2378 |
| format | Article |
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College of Veterinary Medicine, University of Illinois at
Urbana-Champaign, Urbana, Illinois 61801
The present
study was carried out to examine whether nasal strip application would
improve the exercise-induced arterial hypoxemia and hypercapnia, diminish anaerobic metabolism, and modify the incidence of exercise-induced pulmonary hemorrhage (EIPH) in horses. Two sets of experiments, control and nasal strip experiments, were
carried out on seven healthy, sound, exercise-trained Thoroughbred horses in random order, 7 days apart. Simultaneous measurements of core
temperature, arterial and mixed venous blood gases/pH, and blood
lactate and ammonia concentrations were made at rest, during submaximal
and near-maximal exercise, and during recovery. In both treatments,
whereas submaximal exercise caused hyperventilation, near-maximal
exercise induced significant arterial hypoxemia, desaturation of Hb,
hypercapnia, and acidosis. However, O 2 content increased
significantly with exercise in both treatments, while the mixed venous
blood O 2 content decreased as O 2 extraction
increased. In both treatments, plasma ammonia and blood lactate
concentrations increased significantly with exercise. Statistically
significant differences between the control and the nasal strip
experiments could not be discerned, however. Also, all horses
experienced EIPH in both treatments. Thus our data indicated that
application of an external nasal dilator strip neither improved the
exercise-induced arterial hypoxemia and hypercapnia nor diminished
anaerobic metabolism or the incidence of EIPH in Thoroughbred horses
performing strenuous exercise.
nasal dilator strip; blood-gas tensions; lactate production; ammonia production; exercise-induced pulmonary hemorrhage</description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/jappl.2001.90.6.2378</identifier><identifier>PMID: 11356805</identifier><identifier>CODEN: JAPHEV</identifier><language>eng</language><publisher>Bethesda, MD: Am Physiological Soc</publisher><subject>Ammonia - blood ; Anaerobiosis - physiology ; Animals ; Biological and medical sciences ; Blood ; Blood Gas Analysis ; Blood gas. Hemoglobin. Myoglobin. Hemotissulary gas exchange. Acid-base balance ; Body Temperature - physiology ; Endoscopy ; Exercise ; Female ; Fundamental and applied biological sciences. Psychology ; Heart Rate - physiology ; Hemorrhage ; Hemorrhage - etiology ; Hemorrhage - physiopathology ; Horses ; Horses - physiology ; Lactic Acid - blood ; Lung Diseases - etiology ; Lung Diseases - physiopathology ; Lungs ; Male ; Metabolism ; Nasal Cavity - physiology ; Physical Conditioning, Animal ; Physical Exertion - physiology ; Pulmonary Gas Exchange - physiology ; Vertebrates: respiratory system</subject><ispartof>Journal of applied physiology (1985), 2001-06, Vol.90 (6), p.2378-2385</ispartof><rights>2001 INIST-CNRS</rights><rights>Copyright American Physiological Society Jun 2001</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-39a389232a06f4b723e1825e585ccd49c606c51d35f408d0afc161056dac5a093</citedby><cites>FETCH-LOGICAL-c483t-39a389232a06f4b723e1825e585ccd49c606c51d35f408d0afc161056dac5a093</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3039,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1135515$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11356805$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Goetz, Thomas E</creatorcontrib><creatorcontrib>Manohar, Murli</creatorcontrib><creatorcontrib>Hassan, Aslam S</creatorcontrib><creatorcontrib>Baker, Gordon J</creatorcontrib><title>Nasal strips do not affect pulmonary gas exchange, anaerobic metabolism, or EIPH in exercising Thoroughbreds</title><title>Journal of applied physiology (1985)</title><addtitle>J Appl Physiol (1985)</addtitle><description>Departments of Veterinary Clinical Medicine and Biosciences,
College of Veterinary Medicine, University of Illinois at
Urbana-Champaign, Urbana, Illinois 61801
The present
study was carried out to examine whether nasal strip application would
improve the exercise-induced arterial hypoxemia and hypercapnia, diminish anaerobic metabolism, and modify the incidence of exercise-induced pulmonary hemorrhage (EIPH) in horses. Two sets of experiments, control and nasal strip experiments, were
carried out on seven healthy, sound, exercise-trained Thoroughbred horses in random order, 7 days apart. Simultaneous measurements of core
temperature, arterial and mixed venous blood gases/pH, and blood
lactate and ammonia concentrations were made at rest, during submaximal
and near-maximal exercise, and during recovery. In both treatments,
whereas submaximal exercise caused hyperventilation, near-maximal
exercise induced significant arterial hypoxemia, desaturation of Hb,
hypercapnia, and acidosis. However, O 2 content increased
significantly with exercise in both treatments, while the mixed venous
blood O 2 content decreased as O 2 extraction
increased. In both treatments, plasma ammonia and blood lactate
concentrations increased significantly with exercise. Statistically
significant differences between the control and the nasal strip
experiments could not be discerned, however. Also, all horses
experienced EIPH in both treatments. Thus our data indicated that
application of an external nasal dilator strip neither improved the
exercise-induced arterial hypoxemia and hypercapnia nor diminished
anaerobic metabolism or the incidence of EIPH in Thoroughbred horses
performing strenuous exercise.
nasal dilator strip; blood-gas tensions; lactate production; ammonia production; exercise-induced pulmonary hemorrhage</description><subject>Ammonia - blood</subject><subject>Anaerobiosis - physiology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Blood Gas Analysis</subject><subject>Blood gas. Hemoglobin. Myoglobin. Hemotissulary gas exchange. Acid-base balance</subject><subject>Body Temperature - physiology</subject><subject>Endoscopy</subject><subject>Exercise</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Heart Rate - physiology</subject><subject>Hemorrhage</subject><subject>Hemorrhage - etiology</subject><subject>Hemorrhage - physiopathology</subject><subject>Horses</subject><subject>Horses - physiology</subject><subject>Lactic Acid - blood</subject><subject>Lung Diseases - etiology</subject><subject>Lung Diseases - physiopathology</subject><subject>Lungs</subject><subject>Male</subject><subject>Metabolism</subject><subject>Nasal Cavity - physiology</subject><subject>Physical Conditioning, Animal</subject><subject>Physical Exertion - physiology</subject><subject>Pulmonary Gas Exchange - physiology</subject><subject>Vertebrates: respiratory system</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUFv1DAQhSMEotvCP0DIQghxaILt2I5zRFVLK1XAYTlbE8dJvHLiYCdq99_jbVcUkDjNYb438_Relr0huCCE0087mGdXUIxJUeNCFLSs5LNsk1Y0JwKT59lGVhznFZfVSXYa4y6hjHHyMjshpORCYr7J3FeI4FBcgp0jaj2a_IKg64xe0Ly60U8Q9qiHiMy9HmDqzTmCCUzwjdVoNAs03tk4niMf0OXN92tkp4SaoG20U4-2gw9-7YcmmDa-yl504KJ5fZxn2Y-ry-3FdX777cvNxefbXDNZLnlZQylrWlLAomNNRUtDJOWGS651y2otsNCctCXvGJYthk4TQTAXLWgOuC7Psg-Pd-fgf64mLmq0URvnYDJ-jYpIwXBdiQS--wfc-TVMyZuilJJaMFYliD1COvgYg-nUHOyYYlEEq0MV6qEKdahC1VgJdagiyd4eb6_NaNon0TH7BLw_AhA1uC7AlEL7i-OEP70fbD_c2WDUPOyj9c73e3W1Orc198vBwu_Xam67JPv4f1mi_3D6C3qMs3c</recordid><startdate>20010601</startdate><enddate>20010601</enddate><creator>Goetz, Thomas E</creator><creator>Manohar, Murli</creator><creator>Hassan, Aslam S</creator><creator>Baker, Gordon J</creator><general>Am Physiological Soc</general><general>American Physiological Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20010601</creationdate><title>Nasal strips do not affect pulmonary gas exchange, anaerobic metabolism, or EIPH in exercising Thoroughbreds</title><author>Goetz, Thomas E ; Manohar, Murli ; Hassan, Aslam S ; Baker, Gordon J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-39a389232a06f4b723e1825e585ccd49c606c51d35f408d0afc161056dac5a093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Ammonia - blood</topic><topic>Anaerobiosis - physiology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Blood Gas Analysis</topic><topic>Blood gas. Hemoglobin. Myoglobin. Hemotissulary gas exchange. Acid-base balance</topic><topic>Body Temperature - physiology</topic><topic>Endoscopy</topic><topic>Exercise</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Heart Rate - physiology</topic><topic>Hemorrhage</topic><topic>Hemorrhage - etiology</topic><topic>Hemorrhage - physiopathology</topic><topic>Horses</topic><topic>Horses - physiology</topic><topic>Lactic Acid - blood</topic><topic>Lung Diseases - etiology</topic><topic>Lung Diseases - physiopathology</topic><topic>Lungs</topic><topic>Male</topic><topic>Metabolism</topic><topic>Nasal Cavity - physiology</topic><topic>Physical Conditioning, Animal</topic><topic>Physical Exertion - physiology</topic><topic>Pulmonary Gas Exchange - physiology</topic><topic>Vertebrates: respiratory system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goetz, Thomas E</creatorcontrib><creatorcontrib>Manohar, Murli</creatorcontrib><creatorcontrib>Hassan, Aslam S</creatorcontrib><creatorcontrib>Baker, Gordon J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of applied physiology (1985)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goetz, Thomas E</au><au>Manohar, Murli</au><au>Hassan, Aslam S</au><au>Baker, Gordon J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nasal strips do not affect pulmonary gas exchange, anaerobic metabolism, or EIPH in exercising Thoroughbreds</atitle><jtitle>Journal of applied physiology (1985)</jtitle><addtitle>J Appl Physiol (1985)</addtitle><date>2001-06-01</date><risdate>2001</risdate><volume>90</volume><issue>6</issue><spage>2378</spage><epage>2385</epage><pages>2378-2385</pages><issn>8750-7587</issn><eissn>1522-1601</eissn><coden>JAPHEV</coden><abstract>Departments of Veterinary Clinical Medicine and Biosciences,
College of Veterinary Medicine, University of Illinois at
Urbana-Champaign, Urbana, Illinois 61801
The present
study was carried out to examine whether nasal strip application would
improve the exercise-induced arterial hypoxemia and hypercapnia, diminish anaerobic metabolism, and modify the incidence of exercise-induced pulmonary hemorrhage (EIPH) in horses. Two sets of experiments, control and nasal strip experiments, were
carried out on seven healthy, sound, exercise-trained Thoroughbred horses in random order, 7 days apart. Simultaneous measurements of core
temperature, arterial and mixed venous blood gases/pH, and blood
lactate and ammonia concentrations were made at rest, during submaximal
and near-maximal exercise, and during recovery. In both treatments,
whereas submaximal exercise caused hyperventilation, near-maximal
exercise induced significant arterial hypoxemia, desaturation of Hb,
hypercapnia, and acidosis. However, O 2 content increased
significantly with exercise in both treatments, while the mixed venous
blood O 2 content decreased as O 2 extraction
increased. In both treatments, plasma ammonia and blood lactate
concentrations increased significantly with exercise. Statistically
significant differences between the control and the nasal strip
experiments could not be discerned, however. Also, all horses
experienced EIPH in both treatments. Thus our data indicated that
application of an external nasal dilator strip neither improved the
exercise-induced arterial hypoxemia and hypercapnia nor diminished
anaerobic metabolism or the incidence of EIPH in Thoroughbred horses
performing strenuous exercise.
nasal dilator strip; blood-gas tensions; lactate production; ammonia production; exercise-induced pulmonary hemorrhage</abstract><cop>Bethesda, MD</cop><pub>Am Physiological Soc</pub><pmid>11356805</pmid><doi>10.1152/jappl.2001.90.6.2378</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 8750-7587 |
| ispartof | Journal of applied physiology (1985), 2001-06, Vol.90 (6), p.2378-2385 |
| issn | 8750-7587 1522-1601 |
| language | eng |
| recordid | cdi_pubmed_primary_11356805 |
| source | MEDLINE; American Physiological Society Paid; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Ammonia - blood Anaerobiosis - physiology Animals Biological and medical sciences Blood Blood Gas Analysis Blood gas. Hemoglobin. Myoglobin. Hemotissulary gas exchange. Acid-base balance Body Temperature - physiology Endoscopy Exercise Female Fundamental and applied biological sciences. Psychology Heart Rate - physiology Hemorrhage Hemorrhage - etiology Hemorrhage - physiopathology Horses Horses - physiology Lactic Acid - blood Lung Diseases - etiology Lung Diseases - physiopathology Lungs Male Metabolism Nasal Cavity - physiology Physical Conditioning, Animal Physical Exertion - physiology Pulmonary Gas Exchange - physiology Vertebrates: respiratory system |
| title | Nasal strips do not affect pulmonary gas exchange, anaerobic metabolism, or EIPH in exercising Thoroughbreds |
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