The gamma(2)-MSH peptide mediates a central analgesic effect via a GABA-ergic mechanism that is independent from activation of melanocortin receptors

Using the latency for tail-flick after thermal stimulation we have assessed the effects of alpha-, gamma(1)- and gamma(2)-MSH on nociceptive threshold in the mice. Intracisternal injections of gamma(2)-MSH induced a distinct analgesia, while gamma(1)-MSH in the same doses gave only a minor analgesia...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuropeptides (Edinburgh) 2001-02, Vol.35 (1), p.50
Hauptverfasser:	Klusa, V, Germane, S, Svirskis, S, Opmane, B, Wikberg, J E
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-MSH - metabolism alpha-MSH - pharmacology Analgesics - metabolism Analgesics - pharmacology Animals Bicuculline - pharmacology Catalepsy - chemically induced Central Nervous System Depressants - pharmacology Diazepam - pharmacology Drug Interactions Ethanol - pharmacology GABA Agonists - pharmacology GABA Antagonists - pharmacology GABA Modulators - pharmacology gamma-Aminobutyric Acid - metabolism gamma-MSH - metabolism gamma-MSH - pharmacology Male Mice Mice, Inbred BALB C Muscimol - pharmacology Naloxone - pharmacology Narcotic Antagonists - pharmacology Nociceptors - drug effects Nociceptors - physiology Pain Threshold - drug effects Pain Threshold - physiology Peptides, Cyclic - pharmacology Receptors, Corticotropin - metabolism Receptors, Melanocortin Tail
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!