The adenylate cyclase toxin of Bordetella pertussis binds to target cells via the alpha(M)beta(2) integrin (CD11b/CD18)

The adenylate cyclase toxin (CyaA) of Bordetella pertussis is a major virulence factor required for the early phases of lung colonization. It can invade eukaryotic cells where, upon activation by endogenous calmodulin, it catalyzes the formation of unregulated cAMP levels. CyaA intoxication leads to...

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Veröffentlicht in:	The Journal of experimental medicine 2001-05, Vol.193 (9), p.1035
Hauptverfasser:	Guermonprez, P, Khelef, N, Blouin, E, Rieu, P, Ricciardi-Castagnoli, P, Guiso, N, Ladant, D, Leclerc, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylate Cyclase Toxin Adenylyl Cyclases - metabolism Animals Antibodies, Monoclonal - metabolism Bacterial Proteins - metabolism Bordetella pertussis - metabolism Calcium Cations, Divalent CD18 Antigens - genetics CD18 Antigens - metabolism Cell Line CHO Cells Cricetinae Cyclic AMP - metabolism Humans Macrophage-1 Antigen - genetics Macrophage-1 Antigen - metabolism Magnesium Mice Protein Precursors - metabolism Rats
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