Vaccination of a Refractory Essential Monoclonal Cryoglobulinemia Patient with Cryoglobulin-Pulsed Dendritic Cells

We vaccinated a refractory essential monoclonal cryoglobulinemia patient with monocyte-derived DCs (Mo-DCs) pulsed with purified cryoglobulin as a tumor antigen. During the vaccinations, his acrocyanosis improved and we were able to reduce the number of hot baths used to treat his symptoms, with no...

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Veröffentlicht in:Leukemia & lymphoma 2000, Vol.39 (3-4), p.441-446
Hauptverfasser: Maeda, Motoi, Inaba, Shoichi, Nomura, Akihiko, Tokunaga, Yasunobu, Sugio, Yasuhiro, Itoh, Yoshikiyo, Iino, Tadafumi, Otsuka, Teruhisa, Okamura, Seiichi, Niho, Yoshiyuki
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Sprache:eng
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Zusammenfassung:We vaccinated a refractory essential monoclonal cryoglobulinemia patient with monocyte-derived DCs (Mo-DCs) pulsed with purified cryoglobulin as a tumor antigen. During the vaccinations, his acrocyanosis improved and we were able to reduce the number of hot baths used to treat his symptoms, with no sick effects. Furthermore, cryoglobulin-specific proliferative responses were observed after the vaccination. As there wax a recurrence of acrocyanosis after the final vaccination, vaccination with Mo-DCs pulsed with purified cryoglobulin would seem to be a useful treatment for refractory essential monoclonal cryoglobulinemia.
ISSN:1042-8194
1029-2403
DOI:10.3109/10428190009065846