Vaccination of a Refractory Essential Monoclonal Cryoglobulinemia Patient with Cryoglobulin-Pulsed Dendritic Cells
We vaccinated a refractory essential monoclonal cryoglobulinemia patient with monocyte-derived DCs (Mo-DCs) pulsed with purified cryoglobulin as a tumor antigen. During the vaccinations, his acrocyanosis improved and we were able to reduce the number of hot baths used to treat his symptoms, with no...
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Veröffentlicht in: | Leukemia & lymphoma 2000, Vol.39 (3-4), p.441-446 |
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Hauptverfasser: | , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | We vaccinated a refractory essential monoclonal cryoglobulinemia patient with monocyte-derived DCs (Mo-DCs) pulsed with purified cryoglobulin as a tumor antigen. During the vaccinations, his acrocyanosis improved and we were able to reduce the number of hot baths used to treat his symptoms, with no sick effects. Furthermore, cryoglobulin-specific proliferative responses were observed after the vaccination. As there wax a recurrence of acrocyanosis after the final vaccination, vaccination with Mo-DCs pulsed with purified cryoglobulin would seem to be a useful treatment for refractory essential monoclonal cryoglobulinemia. |
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ISSN: | 1042-8194 1029-2403 |
DOI: | 10.3109/10428190009065846 |