A Conserved Threonine within Escherichia coli Leucyl-tRNA Synthetase Prevents Hydrolytic Editing of Leucyl-tRNALeu

Aminoacyl-tRNA synthetases ensure the fidelity of protein synthesis by accurately selecting and activating cognate amino acids for aminoacylation of the correct tRNA. Some tRNA synthetases have evolved an editing active site that is separate from the amino acid activation site providing two steps or...

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Veröffentlicht in:	Biochemistry (Easton) 2001-05, Vol.40 (18), p.5376-5381
Hauptverfasser:	Mursinna, Richard S, Lincecum, Tommie L, Martinis, Susan A
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine - genetics Amino Acid Sequence Amino Acid Substitution - genetics Binding Sites - genetics Conserved Sequence DNA Mutational Analysis Escherichia coli - enzymology Escherichia coli - genetics Hydrolysis Leucine-tRNA Ligase - genetics Leucine-tRNA Ligase - metabolism Molecular Sequence Data Mutagenesis, Site-Directed Protein Structure, Tertiary - genetics RNA Editing - genetics RNA, Transfer, Leu - genetics RNA, Transfer, Leu - metabolism Threonine - genetics Threonine - metabolism Transfer RNA Aminoacylation - genetics
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