Seroprevalence of Human Granulocytic Ehrlichiosis in High-risk Groups in Denmark
The aim of this study was to evaluate the seroprevalence of human granulocytic ehrlichiosis (HGE) among 300 residents in the county of Funen, Denmark. All of these people had either suspected or confirmed borreliosis. Two hundred control sera were included in the study. Samples were submitted by gen...
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| Veröffentlicht in: | Scandinavian journal of infectious diseases 2001, Vol.33 (3), p.206-210 |
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| description | The aim of this study was to evaluate the seroprevalence of human granulocytic ehrlichiosis (HGE) among 300 residents in the county of Funen, Denmark. All of these people had either suspected or confirmed borreliosis. Two hundred control sera were included in the study. Samples were submitted by general practitioners and by hospital departments. An indirect immunofluorescence assay was used to identify sera reactive to HGE and an enzyme-linked immunosorbent assay was used to analyse Borrelia burgdorferi antibodies. There were 63 (21%) HGE-positive sera, 53 of which came from Borrelia-seropositive patients. Among patients with negative Borrelia serology, but with clinical suspicion of borreliosis, 14.3% were HGE-positive (n = 70). Of the 200 control sera, 3.5% were HGE-positive and 10.5% were Borrelia-positive. No HGE-positive samples were found among subjects < 20 y of age, wheras 20.4% of Borrelia seropositive samples where from subjects < 20 y of age. No mortality was observed in the HGE-positive group and the percentage of serum samples positive for both Borrelia and HGE did not differ significantly between hospitalized and non-hospitalized patients. Our study indicates that HGE infection with or without concomitant or previous Borrelia burgdorferi infection is common in tick-exposed individuals > 20 y old in the county of Funen, Denmark. |
| doi_str_mv | 10.1080/00365540151060860 |
| format | Article |
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All of these people had either suspected or confirmed borreliosis. Two hundred control sera were included in the study. Samples were submitted by general practitioners and by hospital departments. An indirect immunofluorescence assay was used to identify sera reactive to HGE and an enzyme-linked immunosorbent assay was used to analyse Borrelia burgdorferi antibodies. There were 63 (21%) HGE-positive sera, 53 of which came from Borrelia-seropositive patients. Among patients with negative Borrelia serology, but with clinical suspicion of borreliosis, 14.3% were HGE-positive (n = 70). Of the 200 control sera, 3.5% were HGE-positive and 10.5% were Borrelia-positive. No HGE-positive samples were found among subjects < 20 y of age, wheras 20.4% of Borrelia seropositive samples where from subjects < 20 y of age. No mortality was observed in the HGE-positive group and the percentage of serum samples positive for both Borrelia and HGE did not differ significantly between hospitalized and non-hospitalized patients. Our study indicates that HGE infection with or without concomitant or previous Borrelia burgdorferi infection is common in tick-exposed individuals > 20 y old in the county of Funen, Denmark.</description><identifier>ISSN: 0036-5548</identifier><identifier>EISSN: 1651-1980</identifier><identifier>DOI: 10.1080/00365540151060860</identifier><identifier>PMID: 11303811</identifier><identifier>CODEN: SJIDB7</identifier><language>eng</language><publisher>Basingstoke: Informa UK Ltd</publisher><subject>Adolescent ; Adult ; Age Distribution ; Aged ; Aged, 80 and over ; Antibodies, Bacterial - blood ; Antibodies, Bacterial - immunology ; Bacterial diseases ; Biological and medical sciences ; Borrelia burgdorferi ; Borrelia Infections - blood ; Borrelia Infections - complications ; Borrelia Infections - immunology ; Child ; Child, Preschool ; Denmark - epidemiology ; Denmark, Funen ; Ehrlichia ; Ehrlichia - immunology ; Ehrlichiosis - complications ; Ehrlichiosis - epidemiology ; Ehrlichiosis - immunology ; Enzyme-Linked Immunosorbent Assay ; Female ; Fluorescent Antibody Technique, Indirect ; Granulocytes - microbiology ; Human bacterial diseases ; human granulocytic ehrlichiosis ; Humans ; Infant ; Infant, Newborn ; Infectious diseases ; Male ; Medical sciences ; Middle Aged ; Rickettsial diseases ; Risk Factors ; Seroepidemiologic Studies ; Sex Distribution ; Tropical bacterial diseases</subject><ispartof>Scandinavian journal of infectious diseases, 2001, Vol.33 (3), p.206-210</ispartof><rights>2001 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2001</rights><rights>2001 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c463t-c057c8be97de25cb92bf652e22fabad2143237c2e8d4e6eddb2c293ad12113123</citedby><cites>FETCH-LOGICAL-c463t-c057c8be97de25cb92bf652e22fabad2143237c2e8d4e6eddb2c293ad12113123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/00365540151060860$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/00365540151060860$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,778,782,4012,27906,27907,27908,59628,59734,60417,60523,61202,61237,61383,61418</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=970462$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11303811$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SKARPHEDINSSON, Sigurdur</creatorcontrib><creatorcontrib>SØGAARD, Per</creatorcontrib><creatorcontrib>PEDERSEN, Court</creatorcontrib><title>Seroprevalence of Human Granulocytic Ehrlichiosis in High-risk Groups in Denmark</title><title>Scandinavian journal of infectious diseases</title><addtitle>Scand J Infect Dis</addtitle><description>The aim of this study was to evaluate the seroprevalence of human granulocytic ehrlichiosis (HGE) among 300 residents in the county of Funen, Denmark. All of these people had either suspected or confirmed borreliosis. Two hundred control sera were included in the study. Samples were submitted by general practitioners and by hospital departments. An indirect immunofluorescence assay was used to identify sera reactive to HGE and an enzyme-linked immunosorbent assay was used to analyse Borrelia burgdorferi antibodies. There were 63 (21%) HGE-positive sera, 53 of which came from Borrelia-seropositive patients. Among patients with negative Borrelia serology, but with clinical suspicion of borreliosis, 14.3% were HGE-positive (n = 70). Of the 200 control sera, 3.5% were HGE-positive and 10.5% were Borrelia-positive. No HGE-positive samples were found among subjects < 20 y of age, wheras 20.4% of Borrelia seropositive samples where from subjects < 20 y of age. No mortality was observed in the HGE-positive group and the percentage of serum samples positive for both Borrelia and HGE did not differ significantly between hospitalized and non-hospitalized patients. Our study indicates that HGE infection with or without concomitant or previous Borrelia burgdorferi infection is common in tick-exposed individuals > 20 y old in the county of Funen, Denmark.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Distribution</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antibodies, Bacterial - blood</subject><subject>Antibodies, Bacterial - immunology</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Borrelia burgdorferi</subject><subject>Borrelia Infections - blood</subject><subject>Borrelia Infections - complications</subject><subject>Borrelia Infections - immunology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Denmark - epidemiology</subject><subject>Denmark, Funen</subject><subject>Ehrlichia</subject><subject>Ehrlichia - immunology</subject><subject>Ehrlichiosis - complications</subject><subject>Ehrlichiosis - epidemiology</subject><subject>Ehrlichiosis - immunology</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Fluorescent Antibody Technique, Indirect</subject><subject>Granulocytes - microbiology</subject><subject>Human bacterial diseases</subject><subject>human granulocytic ehrlichiosis</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Rickettsial diseases</subject><subject>Risk Factors</subject><subject>Seroepidemiologic Studies</subject><subject>Sex Distribution</subject><subject>Tropical bacterial diseases</subject><issn>0036-5548</issn><issn>1651-1980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9r3DAQxUVpaLZJP0AvxVDozemM5D8y7aUkabYQSKHp2cjyuFYiW1vJTthvH21201ACyUkw-r3hvTeMvUc4QpDwGUAUeZ4B5ggFyAJesQUWOaZYSXjNFpv_NAJyn70N4QoAskLAG7aPKEBIxAX7-Yu8W3m6UZZGTYnrkuU8qDE582qcrdPryejktPfW6N64YEJixmRp_vSpN-E6Ym5e3c9OaByUvz5ke52ygd7t3gP2-_vp5fEyPb84-3H87TzV0cOUashLLRuqypZ4rpuKN12Rc-K8U41qOWaCi1Jzkm1GBbVtwzWvhGqRR_PIxQH7tN278u7vTGGqBxM0WatGcnOoyxIKFGX1IoillFkGMoK4BbV3IXjq6pU3MdK6Rqg3fddP-o6aD7vlczNQ-6jYFRyBjztABa1sF1vVJvzjqjKeZBPm65YyY-f8oG6dt209qbV1_kEinnPx5T95T8pOvVae6is3-zHe4ZkMd63JrA8</recordid><startdate>2001</startdate><enddate>2001</enddate><creator>SKARPHEDINSSON, Sigurdur</creator><creator>SØGAARD, Per</creator><creator>PEDERSEN, Court</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>2001</creationdate><title>Seroprevalence of Human Granulocytic Ehrlichiosis in High-risk Groups in Denmark</title><author>SKARPHEDINSSON, Sigurdur ; SØGAARD, Per ; PEDERSEN, Court</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c463t-c057c8be97de25cb92bf652e22fabad2143237c2e8d4e6eddb2c293ad12113123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Distribution</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antibodies, Bacterial - blood</topic><topic>Antibodies, Bacterial - immunology</topic><topic>Bacterial diseases</topic><topic>Biological and medical sciences</topic><topic>Borrelia burgdorferi</topic><topic>Borrelia Infections - blood</topic><topic>Borrelia Infections - complications</topic><topic>Borrelia Infections - immunology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Denmark - epidemiology</topic><topic>Denmark, Funen</topic><topic>Ehrlichia</topic><topic>Ehrlichia - immunology</topic><topic>Ehrlichiosis - complications</topic><topic>Ehrlichiosis - epidemiology</topic><topic>Ehrlichiosis - immunology</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Fluorescent Antibody Technique, Indirect</topic><topic>Granulocytes - microbiology</topic><topic>Human bacterial diseases</topic><topic>human granulocytic ehrlichiosis</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Rickettsial diseases</topic><topic>Risk Factors</topic><topic>Seroepidemiologic Studies</topic><topic>Sex Distribution</topic><topic>Tropical bacterial diseases</topic><toplevel>online_resources</toplevel><creatorcontrib>SKARPHEDINSSON, Sigurdur</creatorcontrib><creatorcontrib>SØGAARD, Per</creatorcontrib><creatorcontrib>PEDERSEN, Court</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Scandinavian journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SKARPHEDINSSON, Sigurdur</au><au>SØGAARD, Per</au><au>PEDERSEN, Court</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Seroprevalence of Human Granulocytic Ehrlichiosis in High-risk Groups in Denmark</atitle><jtitle>Scandinavian journal of infectious diseases</jtitle><addtitle>Scand J Infect Dis</addtitle><date>2001</date><risdate>2001</risdate><volume>33</volume><issue>3</issue><spage>206</spage><epage>210</epage><pages>206-210</pages><issn>0036-5548</issn><eissn>1651-1980</eissn><coden>SJIDB7</coden><abstract>The aim of this study was to evaluate the seroprevalence of human granulocytic ehrlichiosis (HGE) among 300 residents in the county of Funen, Denmark. All of these people had either suspected or confirmed borreliosis. Two hundred control sera were included in the study. Samples were submitted by general practitioners and by hospital departments. An indirect immunofluorescence assay was used to identify sera reactive to HGE and an enzyme-linked immunosorbent assay was used to analyse Borrelia burgdorferi antibodies. There were 63 (21%) HGE-positive sera, 53 of which came from Borrelia-seropositive patients. Among patients with negative Borrelia serology, but with clinical suspicion of borreliosis, 14.3% were HGE-positive (n = 70). Of the 200 control sera, 3.5% were HGE-positive and 10.5% were Borrelia-positive. No HGE-positive samples were found among subjects < 20 y of age, wheras 20.4% of Borrelia seropositive samples where from subjects < 20 y of age. No mortality was observed in the HGE-positive group and the percentage of serum samples positive for both Borrelia and HGE did not differ significantly between hospitalized and non-hospitalized patients. Our study indicates that HGE infection with or without concomitant or previous Borrelia burgdorferi infection is common in tick-exposed individuals > 20 y old in the county of Funen, Denmark.</abstract><cop>Basingstoke</cop><pub>Informa UK Ltd</pub><pmid>11303811</pmid><doi>10.1080/00365540151060860</doi><tpages>5</tpages></addata></record> |
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| ispartof | Scandinavian journal of infectious diseases, 2001, Vol.33 (3), p.206-210 |
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| subjects | Adolescent Adult Age Distribution Aged Aged, 80 and over Antibodies, Bacterial - blood Antibodies, Bacterial - immunology Bacterial diseases Biological and medical sciences Borrelia burgdorferi Borrelia Infections - blood Borrelia Infections - complications Borrelia Infections - immunology Child Child, Preschool Denmark - epidemiology Denmark, Funen Ehrlichia Ehrlichia - immunology Ehrlichiosis - complications Ehrlichiosis - epidemiology Ehrlichiosis - immunology Enzyme-Linked Immunosorbent Assay Female Fluorescent Antibody Technique, Indirect Granulocytes - microbiology Human bacterial diseases human granulocytic ehrlichiosis Humans Infant Infant, Newborn Infectious diseases Male Medical sciences Middle Aged Rickettsial diseases Risk Factors Seroepidemiologic Studies Sex Distribution Tropical bacterial diseases |
| title | Seroprevalence of Human Granulocytic Ehrlichiosis in High-risk Groups in Denmark |
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