Differentiation of Embryonic Mesenchymal Cells to Odontoblast-like Cells by Overexpression of Dentin Matrix Protein 1

Cells of the craniofacial skeleton are derived from a common mesenchymal progenitor. The regulatory factors that control their differentiation into various cell lineages are unknown. To investigate the biological function of dentin matrix protein 1 (DMP1), an extracellular matrix gene involved in ca...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2001-04, Vol.98 (8), p.4516-4521
Hauptverfasser:	Narayanan, Karthikeyan, Srinivas, Rampalli, Ramachandran, Amsaveni, Hao, Jianjun, Quinn, Bruce, George, Anne
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals Biological Sciences Casein Kinase II Cell Differentiation Cell Lineage Cell lines Cellular differentiation Chondrocytes Core Binding Factor Alpha 1 Subunit Core Binding Factors dentin matrix protein 1 Embryo, Mammalian - cytology Embryo, Mammalian - metabolism Extracellular Matrix Proteins Gene Expression Regulation, Developmental Gene Transfer Techniques Genes Mesenchymal stem cells Mice Mice, Inbred C3H Mitogen-Activated Protein Kinases - metabolism Neoplasm Proteins Odontoblasts Odontoblasts - cytology Phosphoproteins - genetics Phosphoproteins - metabolism Phosphorylation Pluripotent stem cells Protein-Serine-Threonine Kinases - metabolism Reverse transcriptase polymerase chain reaction Teeth Transcription Factors - metabolism transgenes
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