Liposomal Bleomycin: Increased Therapeutic Activity and Decreased Pulmonary Toxicity in Mice

Conventional and sterically stabilized liposomes derived from phosphatidylcholine or the antitumor agents, hexadecylphosphocholine and octadecyl-(1,1-dimethyl-4-piperidino-4-yl)-phosphate, as bilayer forming constituents, containing bleomycin, were developed and tested. Liposomal encapsulation of bl...

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Veröffentlicht in:	Drug delivery 2001-01, Vol.8 (1), p.1-7
1. Verfasser:	Arndt, R. Zeisig, D. Bechtel, I. Fichtner, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics, Antineoplastic - administration & dosage Antibiotics, Antineoplastic - toxicity bleomycin Bleomycin - administration & dosage Bleomycin - toxicity Bleomycin Increased Antitumor Activity P388 Leukemia Lewis Lung Tumor (LLT) Liposomes Dose-Response Relationship, Drug Drug Delivery Systems Female Liposomes Lung - drug effects Lung Diseases - prevention & control Mice Neoplasms, Experimental - drug therapy
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