Mouse Skin Tumorigenesis and Induction of Aryl Hydrocarbon Hydroxylase by Tobacco Smoke Fractions
Ten fractions separated from the neutral portion of cigarette smoke condensate (CSC) were tested on mouse skin for tumor-initiating activity and for their capacity to induce the enzyme aryl hydrocarbon hydroxylase (AHH). Tumor-initiating activity was confined primarily to the fraction containing mor...
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| Veröffentlicht in: | JNCI : Journal of the National Cancer Institute 1975-04, Vol.54 (4), p.907-912 |
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| container_title | JNCI : Journal of the National Cancer Institute |
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| creator | Akin, F J Chamberlain, W J Chortyk, O T |
| description | Ten fractions separated from the neutral portion of cigarette smoke condensate (CSC) were tested on mouse skin for tumor-initiating activity and for their capacity to induce the enzyme aryl hydrocarbon hydroxylase (AHH). Tumor-initiating activity was confined primarily to the fraction containing more than 90% of the polynuclear aromatic hydrocarbons (PAH) in CSC. One other PAH-containing fraction was active. The combined initiating effect of these fractions was comparable to that of a 40-ppm solution of benzo[a]pyrene (BP), which is about 40 times the BP content of CSC. Some of the neutral fractions that have been demonstrated to cause tumor promotion in mice pretreated with 7,12-dimethylbenz[ a]anthracene were inactive as tumor initiators. The fractions that contained aromatic hydrocarbons induced mouse skin AHH levels twofold to sixfold after a single topical application. AHH-inducing activity was not, however, a reliable indicator of the carcinogenic potential of a fraction |
| doi_str_mv | 10.1093/jnci/54.4.907 |
| format | Article |
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Tumor-initiating activity was confined primarily to the fraction containing more than 90% of the polynuclear aromatic hydrocarbons (PAH) in CSC. One other PAH-containing fraction was active. The combined initiating effect of these fractions was comparable to that of a 40-ppm solution of benzo[a]pyrene (BP), which is about 40 times the BP content of CSC. Some of the neutral fractions that have been demonstrated to cause tumor promotion in mice pretreated with 7,12-dimethylbenz[ a]anthracene were inactive as tumor initiators. The fractions that contained aromatic hydrocarbons induced mouse skin AHH levels twofold to sixfold after a single topical application. AHH-inducing activity was not, however, a reliable indicator of the carcinogenic potential of a fraction</description><identifier>ISSN: 0027-8874</identifier><identifier>EISSN: 1460-2105</identifier><identifier>DOI: 10.1093/jnci/54.4.907</identifier><identifier>PMID: 1127720</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Animals ; Aryl Hydrocarbon Hydroxylases - biosynthesis ; Benz(a)Anthracenes ; Benzopyrenes ; Carcinogens ; Chemical Fractionation ; Enzyme Induction ; Female ; Hydrocarbons ; Mice ; Mice, Inbred ICR ; Neoplasms, Experimental - chemically induced ; Skin - enzymology ; Skin Neoplasms - chemically induced ; Smoking</subject><ispartof>JNCI : Journal of the National Cancer Institute, 1975-04, Vol.54 (4), p.907-912</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1127720$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Akin, F J</creatorcontrib><creatorcontrib>Chamberlain, W J</creatorcontrib><creatorcontrib>Chortyk, O T</creatorcontrib><title>Mouse Skin Tumorigenesis and Induction of Aryl Hydrocarbon Hydroxylase by Tobacco Smoke Fractions</title><title>JNCI : Journal of the National Cancer Institute</title><addtitle>Journal of the National Cancer Institute</addtitle><description>Ten fractions separated from the neutral portion of cigarette smoke condensate (CSC) were tested on mouse skin for tumor-initiating activity and for their capacity to induce the enzyme aryl hydrocarbon hydroxylase (AHH). Tumor-initiating activity was confined primarily to the fraction containing more than 90% of the polynuclear aromatic hydrocarbons (PAH) in CSC. One other PAH-containing fraction was active. The combined initiating effect of these fractions was comparable to that of a 40-ppm solution of benzo[a]pyrene (BP), which is about 40 times the BP content of CSC. Some of the neutral fractions that have been demonstrated to cause tumor promotion in mice pretreated with 7,12-dimethylbenz[ a]anthracene were inactive as tumor initiators. The fractions that contained aromatic hydrocarbons induced mouse skin AHH levels twofold to sixfold after a single topical application. AHH-inducing activity was not, however, a reliable indicator of the carcinogenic potential of a fraction</description><subject>Animals</subject><subject>Aryl Hydrocarbon Hydroxylases - biosynthesis</subject><subject>Benz(a)Anthracenes</subject><subject>Benzopyrenes</subject><subject>Carcinogens</subject><subject>Chemical Fractionation</subject><subject>Enzyme Induction</subject><subject>Female</subject><subject>Hydrocarbons</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Neoplasms, Experimental - chemically induced</subject><subject>Skin - enzymology</subject><subject>Skin Neoplasms - chemically induced</subject><subject>Smoking</subject><issn>0027-8874</issn><issn>1460-2105</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9j0trAjEUhUNpsdZ22WUhf2A07zhLkVoF7QMtLW6Gm0mmxMdEMg44_76DlZ7NPZyPe-Ag9EhJn5KUDzZl7gdS9EU_JfoKdalQJGGUyGvUJYTpZDjU4hbdVdWGtEqZ6KAOpUxrRroIFqGuHF5ufYlX9T5E_-NKV_kKQ2nxrLR1fvShxKHAo9js8LSxMeQQTZud_anZQVtgGrwKBvI84OU-bB2eRDh_VvfopoBd5R4ut4c-J8-r8TSZv73MxqN54pkQxwRUyhUByiE1ekhUUeSpkkQy4yQUUtmUWWUKINJqZcBYC4wr4VrDJOE576Gnv95DbfbOZofo9xCb7DK15ckf99XRnf4xxG2mNNcym36vsw_xtWD09T1b81_fS2ay</recordid><startdate>197504</startdate><enddate>197504</enddate><creator>Akin, F J</creator><creator>Chamberlain, W J</creator><creator>Chortyk, O T</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>197504</creationdate><title>Mouse Skin Tumorigenesis and Induction of Aryl Hydrocarbon Hydroxylase by Tobacco Smoke Fractions</title><author>Akin, F J ; Chamberlain, W J ; Chortyk, O T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i244t-a69360a13a9b7806ffc965052be5af56d92d6bfa05d76babdda2364ebdd2503c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><topic>Animals</topic><topic>Aryl Hydrocarbon Hydroxylases - biosynthesis</topic><topic>Benz(a)Anthracenes</topic><topic>Benzopyrenes</topic><topic>Carcinogens</topic><topic>Chemical Fractionation</topic><topic>Enzyme Induction</topic><topic>Female</topic><topic>Hydrocarbons</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Neoplasms, Experimental - chemically induced</topic><topic>Skin - enzymology</topic><topic>Skin Neoplasms - chemically induced</topic><topic>Smoking</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akin, F J</creatorcontrib><creatorcontrib>Chamberlain, W J</creatorcontrib><creatorcontrib>Chortyk, O T</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>JNCI : Journal of the National Cancer Institute</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akin, F J</au><au>Chamberlain, W J</au><au>Chortyk, O T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mouse Skin Tumorigenesis and Induction of Aryl Hydrocarbon Hydroxylase by Tobacco Smoke Fractions</atitle><jtitle>JNCI : Journal of the National Cancer Institute</jtitle><addtitle>Journal of the National Cancer Institute</addtitle><date>1975-04</date><risdate>1975</risdate><volume>54</volume><issue>4</issue><spage>907</spage><epage>912</epage><pages>907-912</pages><issn>0027-8874</issn><eissn>1460-2105</eissn><abstract>Ten fractions separated from the neutral portion of cigarette smoke condensate (CSC) were tested on mouse skin for tumor-initiating activity and for their capacity to induce the enzyme aryl hydrocarbon hydroxylase (AHH). Tumor-initiating activity was confined primarily to the fraction containing more than 90% of the polynuclear aromatic hydrocarbons (PAH) in CSC. One other PAH-containing fraction was active. The combined initiating effect of these fractions was comparable to that of a 40-ppm solution of benzo[a]pyrene (BP), which is about 40 times the BP content of CSC. Some of the neutral fractions that have been demonstrated to cause tumor promotion in mice pretreated with 7,12-dimethylbenz[ a]anthracene were inactive as tumor initiators. The fractions that contained aromatic hydrocarbons induced mouse skin AHH levels twofold to sixfold after a single topical application. AHH-inducing activity was not, however, a reliable indicator of the carcinogenic potential of a fraction</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>1127720</pmid><doi>10.1093/jnci/54.4.907</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0027-8874 |
| ispartof | JNCI : Journal of the National Cancer Institute, 1975-04, Vol.54 (4), p.907-912 |
| issn | 0027-8874 1460-2105 |
| language | eng |
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| source | Oxford University Press Journals Digital Archive legacy; MEDLINE |
| subjects | Animals Aryl Hydrocarbon Hydroxylases - biosynthesis Benz(a)Anthracenes Benzopyrenes Carcinogens Chemical Fractionation Enzyme Induction Female Hydrocarbons Mice Mice, Inbred ICR Neoplasms, Experimental - chemically induced Skin - enzymology Skin Neoplasms - chemically induced Smoking |
| title | Mouse Skin Tumorigenesis and Induction of Aryl Hydrocarbon Hydroxylase by Tobacco Smoke Fractions |
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